Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 80 years old.
• People who have had an acute stroke caused by a blockage in a major blood vessel in the front part of the brain, confirmed by a specialised imaging scan (such as CTA, MRA, or DSA).
• People whose stroke severity, measured by a standard medical scale called the NIHSS, falls between 6 and 25 before being enrolled in the trial.
• People who were largely independent before the stroke (scored 0 or 1 on a disability scale called the Modified Rankin Scale).
• People for whom the procedure to access a blood vessel (arterial puncture) was started within 24 hours of when symptoms began or when they were last seen to be well.
• People whose brain imaging results meet certain minimum thresholds — for strokes within 6 hours, a brain scan score of 6 or above on a scale called ASPECTS; for strokes between 6 and 24 hours, the imaging must meet the specific criteria used in either the DAWN or DEFUSE-3 clinical trials (confirm with trial site).
• People (or their legal representative) who have signed a consent form agreeing to take part.

Who may not be able to join:

• People whose initial brain scan shows a stroke affecting multiple separate blood vessel areas in the brain.
• People whose initial brain scan shows a torn artery (arterial dissection).
• People who have any bleeding in the brain before the clot removal procedure.
• People with known allergies or intolerances to blood-thinning medications, iodine-based contrast dye used in scans, or anaesthetic medicines.
• People with a serious active infection (such as blood poisoning/sepsis) or failure of multiple body organs.
• People with a known inherited or acquired bleeding disorder, a deficiency in clotting factors, or those on blood-thinning tablets with a specific clotting test result (INR) above 3; people who have taken a specific type of blood thinner (factor Xa inhibitor) within the past 48 hours must have a normal result on another clotting test (APTT).
• People with a very low platelet count (below 50 × 10⁹/L) on initial blood tests.
• People with blood sugar levels that are very low (below 50 mg/dL) or very high (above 400 mg/dL).
• People with very high blood pressure that cannot be brought under control with medication (consistently above 185 mmHg systolic or 110 mmHg diastolic).
• People who had significant heart failure symptoms before the stroke (confirm with trial site what the NYHA classification threshold means for this criterion).
• People with untreated moderate or severe narrowing of the heart's arteries, or people who have previously had coronary artery bypass surgery.
• People currently on kidney dialysis (haemodialysis or peritoneal dialysis), or people with severely reduced kidney function based on blood test results.
• People with a known brain aneurysm or an abnormal tangle of blood vessels in the brain (arteriovenous malformation).
• People with a cancerous brain tumour or an infection of the central nervous system.
• People with a pre-existing neurological or psychiatric condition (such as dementia or serious mental illness) that would affect the ability to assess their recovery.
• People who are pregnant or breastfeeding at the time of admission.
• People whose life expectancy is estimated to be less than 6 months.
• People who are currently taking part in another clinical trial of an investigational drug or device.
• People considered unsuitable for the trial by the responsible treating clinician for other medical reasons.

Important: Always verify eligibility with the trial site directly before applying.