Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• Your symptoms match those of a new acute stroke, and the medical team considers it unlikely to be a condition mimicking a stroke
• You have not had a stroke in the last 3 months
• It has been 9 hours or less since you were last known to be well before your stroke symptoms started
• You meet one of these three conditions: your stroke severity score (NIHSS) is 6 or higher AND a blocked artery in your brain has been confirmed by a scan; OR your stroke severity score is 6 or higher AND a specific sign of artery blockage is visible on a standard brain scan; OR your stroke severity score is 12 or higher (confirm with trial site)
• You are alert and largely conscious, as shown by a near-normal score on the consciousness part of the stroke severity assessment
• You had little to no disability in daily life before this stroke
• Your brain scan shows that a large enough area of your brain is still healthy (a score of at least 6 on a specific brain scan scale)
• You are already being planned for transfer to a hospital that can perform a procedure to remove or treat the clot in your brain
• You or your legal representative has signed a consent form agreeing to take part

Who may not be able to join:

• You have a known history of severe lung disease, severe heart failure (Class III or IV), a current lung infection, or inhaled material into your lungs before enrolling
• Your breathing rate is very slow (10 breaths per minute or fewer) or very fast (30 breaths per minute or more)
• You already need extra oxygen or a breathing machine to keep your blood oxygen levels stable
• You had a seizure at the time your stroke started
• You are experiencing vomiting, a very severe headache, or loss of consciousness
• Your stroke symptoms were getting better quickly, or you may have had a mini-stroke (TIA) before giving consent
• Your symptoms suggest bleeding around the brain (subarachnoid hemorrhage), even if your scan appears normal
• A brain scan shows a tumour (other than a small, specific type) or an abnormal tangle of blood vessels in your brain
• You are a woman of childbearing age and are known to be pregnant or have a positive pregnancy test
• You have another serious illness that means you are not expected to live for at least 90 days
• It is unlikely that you will be able to complete a follow-up appointment 90 days after the trial
• You are currently taking part in another clinical treatment trial, or finished one within the last 30 days
• You are already taking certain other brain-protecting medications (confirm with trial site)
• A brain scan shows active bleeding inside your brain
• A brain scan shows that brain structures have shifted out of their normal position due to swelling or pressure

Important: Always verify eligibility with the trial site directly before applying.