Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are currently admitted to a hospital or attending as an outpatient.
• People who are able to show they can understand and agree to take part in research, as measured by a standard assessment tool.
• People who have been diagnosed with Schizophrenia or Schizoaffective Disorder (as confirmed by a structured clinical interview) for at least 2 years.
• People who are 18 years of age or older.
• People whose symptoms have not responded well enough to at least 2 different antipsychotic medications taken at an adequate dose for at least 6 weeks each.
• People whose symptoms are at least moderately severe on specific measures of psychosis, based on a standard rating scale assessment at the start of the trial.
• People who a psychiatrist and anaesthesiologist have assessed as suitable to receive a type of brain stimulation therapy involving brief electrical or magnetic pulses.
• People who are currently taking an antipsychotic medication at an adequate dose and are willing to keep that medication the same throughout the main treatment phase of the trial.
• People who are able to attend and follow the trial's treatment schedule.
• People who meet the safety requirements for the specific brain stimulation treatment used in this trial (confirm with trial site).
• Women who could become pregnant must be willing to provide a negative pregnancy test and agree not to become pregnant during the trial.

Who may not be able to join:

• People who have been diagnosed with a substance use disorder (not including nicotine or caffeine) within the past three months.
• People who have a serious and unstable physical health condition alongside their mental health condition.
• People who are pregnant or plan to become pregnant during the trial.
• People who are assessed by the study team as likely having dementia.
• People who have a significant neurological condition that may involve increased pressure in the brain or a growth or abnormality in the brain, such as a brain aneurysm.
• People who have a serious medical condition that may affect their ability to safely participate (confirm with trial site for specific details).
• People who have a metal implant inside or near the head — such as clips, shunts, stimulators, cochlear implants, or electrodes — that cannot be safely removed before the procedure.
• People who need to take benzodiazepine medication at a dose higher than the equivalent of 2 mg of lorazepam per day, or who need to take anti-seizure medications, as these may reduce how well the treatment works.
• People who are not able to communicate in English well enough to complete the memory and thinking tests used in the trial.
• People who have a sensory impairment — such as significant difficulty hearing or seeing — that cannot be corrected and would prevent them from completing the thinking and memory tests.

Important: Always verify eligibility with the trial site directly before applying.