Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged over 18 years old.
• People who have been diagnosed with breast cancer that has not spread to other parts of the body, and who are planned to receive a chemotherapy drug called paclitaxel (given weekly) either before or after surgery.
• People whose general health and ability to carry out daily activities falls within a certain range, measured using a standard scale called the ECOG performance status (scores 0 to 2, meaning fully active to capable of limited self-care — confirm with trial site).

Who may not be able to join:

• People who already have a nerve pain or nerve damage condition before joining the trial.
• People who have diabetes.
• People who have a history of seizures or epilepsy.
• People who have reduced kidney function or reduced liver function beyond certain levels (confirm with trial site for specific thresholds).
• People whose blood counts — specifically white blood cells or platelets — are below certain levels, indicating the bone marrow is not working well enough (confirm with trial site for specific thresholds).
• People who are currently taking vitamin B1, B6, B9, or B12 supplements.
• People who are currently taking certain medications that may cause nerve damage, including amiodarone, colchicine, metronidazole, some tuberculosis treatments, certain HIV medications, or phenytoin.
• People who are currently taking gabapentinoids (a type of nerve pain medication), antidepressants, or opioid pain medications.
• People who are pregnant or breastfeeding.
• People who have had an allergic reaction to a drug called memantine in the past.

Important: Always verify eligibility with the trial site directly before applying.