Oesophageal Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults who have not had a scope procedure to look at the inside of their oesophagus and stomach (called an EGD or upper endoscopy) in the past ten years
- People who are able to read, understand, and sign a written consent form agreeing to take part
- People who do not have a known bleeding disorder, are not taking regular blood-thinning medications, and do not have swollen veins in the oesophagus (varices)
- People who do not have significant trouble swallowing or painful swallowing
- People who do not have heartburn or acid reflux symptoms, and are not taking medications for reflux
- Adults over the age of 50 who also have two or more of the following risk factors for Barrett's oesophagus: carrying extra weight around the middle (waist over 35 inches for women or over 40 inches for men), currently smoking or having smoked more than 10 pack-years, being of white race, being male, or having a confirmed family history of Barrett's oesophagus or a related cancer in at least two family members (with at least one being a close/first-degree relative)
Who may not be able to join:
- People who have had an upper endoscopy (EGD) procedure within the past ten years
- People who are unable to provide written informed consent
- People who have had heartburn or regurgitation happening weekly or more often for five or more years
- People on blood-thinning medications that cannot be temporarily stopped, or who have a bleeding disorder with a specific blood test result (INR) above 1.5
- People with a known history of swollen veins in the oesophagus (varices) or a narrowing of the oesophagus (stricture)
- People for whom the trial doctor determines there is any medical reason that makes it unsafe to undergo the study procedures, including those with a history of pouches in the oesophagus (diverticula), an abnormal opening in the oesophagus (fistula), or an oesophageal ulcer
- People with a history of difficulty swallowing or painful swallowing, including difficulty swallowing pills
- People with a tumour in the throat or mouth area
- People who have had surgery on their oesophagus or stomach, except for a straightforward anti-reflux (fundoplication) surgery without complications
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Amitabh Chak, MD, University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Phone: 216-844-3853
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Positive predictive value for Barret's Esophagus in EsoCheck/EsoGuard positive participants; Barrett's Esophagus prevalence in EsoCheck/EsoGuard test negative subjects from a high-risk GERD negative population; Tissue origins of true positive versus false positive EsoCheck/EsoGuard tests in non-GERD screening population
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.