Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a specific type of cancer (adenocarcinoma) of the oesophagus (food pipe) or the area where the oesophagus meets the stomach, confirmed by a tissue test, and the cancer has not spread too far and can be removed by surgery.
• You are planning to receive chemotherapy combined with radiotherapy before surgery (called neoadjuvant chemoradiotherapy).
• You are 18 years of age or older.
• You are generally well enough to carry out light daily activities — not bedridden or severely limited by your illness (confirm with trial site).
• Your blood, kidney, and liver are working well enough, based on blood test results meeting specific levels set by the trial.
• You are willing to have two additional camera examinations of your oesophagus (endoscopies) for research purposes.
• You are able and willing to sign a consent form agreeing to take part voluntarily.
• You are able to attend follow-up appointments and receive treatment at the trial centre.

Who may not be able to join:

• You have been diagnosed with type 1 or type 2 diabetes and are currently taking medication to manage it.
• You are currently taking metformin or any other diabetes medication for any reason.
• You are allergic or have had a bad reaction to metformin.
• You drink excessive amounts of alcohol.
• You are currently taking certain medications that affect how the body processes specific drugs — including verapamil, cimetidine, dolutegravir, rifampicin, trimethoprim, vandetanib, crizotinib, olaparib, or isavuconazole (confirm with trial site if unsure about your medications).
• You are currently taking medicines that suppress the immune system, such as steroids (corticosteroids), cyclosporine, tacrolimus, sirolimus, everolimus, or cyclophosphamide.
• You have previously had chemotherapy, other systemic cancer treatment, or radiotherapy to the oesophagus.
• Your kidneys are not working well enough, based on a specific blood test result.
• You have had another type of cancer in the past 5 years, or currently have another cancer, that could affect your outlook with oesophageal cancer.
• You have received systemic treatment for any other cancer within the last six months.
• You have previously had a stem cell transplant or a solid organ transplant (such as a kidney or liver transplant).
• You are pregnant, planning to become pregnant, or are currently breastfeeding.
• You have a significant heart condition, such as a recent heart attack, unstable chest pain, heart failure, or a serious irregular heartbeat, that would make major surgery unsafe.
• You have a serious lung condition, such as pulmonary fibrosis or active lung inflammation, that would make major surgery or radiation unsafe.
• You have another serious medical condition that would prevent you from safely receiving the planned treatment, or you have previously had an allergic reaction to certain drugs (such as teniposide or cyclosporine) (confirm with trial site).
• You have dementia or a condition that affects your ability to understand and agree to take part in the trial.

Important: Always verify eligibility with the trial site directly before applying.