Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

General requirements (all groups):

• Adults aged 18 or older who have been referred for a radiotherapy treatment plan that matches one of the specific cancer groups in the trial
• People with a general health and activity level that falls within a certain range (rated 0–3 on a standard medical scale, where 0 means fully active and 3 means limited self-care ability)
• People who have signed and dated a consent form before any study procedures begin

Prostate cancer group:

• People approved for radiotherapy to the prostate and nearby pelvic lymph nodes
• People with prostate cancer confirmed by a tissue sample (biopsy)
• People whose cancer has been assessed as a certain stage based on tumour size and spread (cT1–4)
• People where cancer has been found in nearby lymph nodes, confirmed by a specialised scan (PSMA-PET/CT) or by a surgical procedure
• People where no distant spread has been found on a PSMA-PET/CT scan, or those with limited distant spread who are still being considered for local radiotherapy

Cervical cancer group:

• People approved for radiotherapy to the cervix and pelvic lymph nodes (25 treatment sessions, followed by an additional targeted radiation boost)
• People with cervical cancer confirmed by a tissue sample
• People whose cancer falls within certain staging categories (FIGO IIA2, IB3 greater than 6cm, IIB–IVA, or with lymph node involvement), or those at another stage who are not suitable for surgery
• People with either no distant spread or some distant spread, where the treating team has approved a full course of local radiation treatment over 25 sessions

Bladder cancer group:

• People approved for radiotherapy to the bladder (whole bladder or a targeted boost to the tumour area)
• People with bladder cancer confirmed by a tissue sample
• People whose cancer has been assessed within a certain stage range (cT1–4)
• People where lymph nodes are either clear or have a limited level of involvement after initial treatment

Lung cancer group:

• People approved for radiotherapy for lung cancer that has spread to nearby lymph nodes
• People with non-small cell lung cancer, either confirmed by tissue sample or with strong enough clinical evidence to treat with radiotherapy
• People whose cancer falls within certain tumour and lymph node stage ranges (cT1–4, cN1–3)
• People with either no distant spread or some distant spread, where the treating team has approved a radical course of radiotherapy over 24 sessions

Head and neck cancer group:

• People approved for radiotherapy for head and neck cancer
• People with cancer of the throat, mouth, or voice box confirmed by a tissue sample
• People whose cancer falls within certain tumour stage ranges (cT1–4) with any level of lymph node involvement, and where radiation to one or both sides of the neck is planned
• People where no distant spread has been found

Who may not be able to join:

General (all groups):

• People who are pregnant

Prostate cancer group:

• People with a medical condition that significantly affects the quality of imaging scans used during treatment (for example, having a hip replacement)
• People with severe urinary symptoms that the treating doctor believes could make the longer treatment sessions difficult to manage

Cervical cancer group:

• People with a medical condition that significantly affects the quality of imaging scans used during treatment (for example, having a hip replacement)

Bladder cancer group:

• People with a medical condition that significantly affects the quality of imaging scans used during treatment (for example, having a hip replacement)
• People with severe urinary symptoms that the treating doctor believes could make the longer treatment sessions difficult to manage

Lung cancer group:

• People with severe breathing difficulties that the treating doctor believes could make the longer treatment sessions difficult to manage

Head and neck cancer group:

• People with severe symptoms that the treating doctor believes could make the longer treatment sessions difficult to manage
• People with a lung condition called pulmonary fibrosis (scarring of the lungs)

Important: Always verify eligibility with the trial site directly before applying.