Phase 4 Asthma Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who are willing and able to give their informed consent before any study procedures begin
- People aged 18 to 55 years (male or female)
- People who have been diagnosed with asthma by a doctor
- People who have been prescribed a high-dose inhaled corticosteroid (a strong preventer inhaler) plus at least one other asthma controller medication for at least 3 months before joining the trial
- People who have had at least one moderate or severe asthma flare-up in the past 12 months
- Women of childbearing age who have a negative pregnancy test at the start of the trial
- Women who are at least 1 year past menopause, have had a surgical procedure that prevents pregnancy, or are using an approved combination of contraception methods for the duration of the study and for 3 months after the last dose of study medication (a barrier method with spermicide is required; oral contraception alone is not sufficient, but can be used alongside a barrier method with spermicide)
- Blood donors who are willing not to donate blood during the study and for 3 months after the last dose of study medication
- People who are willing and able to follow all study procedures
Who may not be able to join:
- People who are involved in planning or running this study
- People who have previously been enrolled in this same trial
- People who have taken part in another clinical trial involving an experimental treatment in the last 6 months
- People with a known allergy or sensitivity to Tezepelumab or any of its ingredients
- People who are hospitalised at the time of their screening appointment
- People who test positive for Hepatitis B or Hepatitis C at screening
- People who are known to be HIV positive
- Current smokers with a smoking history of more than 10 pack-years, ex-smokers with a smoking history of more than 10 pack-years, or people who use e-cigarettes (current smokers with a history of fewer than 10 pack-years may be permitted)
- People with a known history of drug or alcohol misuse within the past year
- People taking certain medications known to affect heart rhythm in specific ways (confirm with trial site)
- People who have previously had to stop a medication due to its effect on heart rhythm (a condition called QT prolongation)
- People born with a heart condition called congenital long QT syndrome
- People whose kidneys are not functioning well enough, based on a specific calculation (confirm with trial site)
- Women who are currently pregnant or breastfeeding
- People with certain types of heart rhythm problems that cause symptoms or require treatment; however, people with atrial fibrillation that is well controlled with medication may be permitted (confirm with trial site)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Irvin Mayers, MD, University of Alberta
Phone: 7804923741
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Proportion of patients who have moderate and severe exacerbations of asthma
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.