Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (male or female)
• You have been diagnosed with a blood cancer called CLL or SLL with symptoms, and have already tried at least 2 previous treatments including specific targeted therapies (BTK inhibitor and venetoclax, or you declined venetoclax), OR you have a type of slow-growing lymphoma (such as marginal zone lymphoma or Waldenstrom's macroglobulinemia) and have had at least 2 prior treatments including specific targeted therapies (confirm with trial site for your specific diagnosis)
• Alternatively, for a different part of the trial: you have symptomatic CLL or SLL, have had at least 1 prior treatment including a BTK inhibitor, and have never received venetoclax
• Your bone marrow, liver, and kidneys are working well enough based on blood tests done within 7 days before starting the study drug (confirm specific values with trial site)
• Your general health and ability to care for yourself meets a certain minimum level (confirm with trial site)
• If you are a woman who could become pregnant, you have a negative pregnancy test within 7 days before starting the study drug, and you agree to use highly effective birth control from signing consent until 90 days after your last dose
• You are able to understand the study and are willing to sign a consent form

Who may not be able to join:

• You have an active, aggressive transformation of your blood cancer called Richter's transformation (however, if you were treated for this and have been in remission for more than 2 years with no signs of it returning, you may still be eligible)
• You have a known allergy or sensitivity to the study drug or any of its ingredients
• You have significant heart problems, such as moderate-to-severe heart failure, uncontrolled heart disease, a heart attack in the past 6 months, or a heart rhythm problem requiring certain medications
• You have an active infection with CMV, hepatitis B, or hepatitis C
• You currently have an active COVID-19 infection (prior COVID-19 is allowed if you fully recovered more than 14 days ago)
• You have a serious active infection that requires intravenous antibiotics or similar treatment (you may be eligible once the infection clears)
• You have certain uncontrolled blood conditions affecting red blood cells or platelets that started within the past 28 days
• You had a bone marrow transplant from a donor less than 4 months ago, or you are still on medications to suppress your immune system after a transplant
• You have another active cancer that is expected to limit your survival to less than 2 years, or that requires active treatment at the same time as this trial (certain early-stage or hormonally treated cancers may be exceptions — confirm with trial site)
• You have a physical finding or test result that the doctor believes makes it unsafe for you to participate
• You still have significant side effects (grade 2 or higher) from a previous cancer treatment that have not resolved (hair loss is an exception)
• You currently need ongoing immune-suppressing medications, including regular steroid pills or infusions for cancer or other conditions (low-dose steroids or inhaled/topical steroids may be acceptable — confirm with trial site)
• You had major surgery or a serious injury within 4 weeks before starting the study drug
• You are currently breastfeeding (you would need to stop breastfeeding before and during treatment, and for at least 3 months after the last dose)
• You have a specific heart rhythm measurement (called QTcF) that is too prolonged and cannot be corrected with standard measures (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.