Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 19 to 79 years old
• People whose general physical functioning is rated at a level showing they are able to carry out some daily activities, even if limited (a score of 2 or below on a standard cancer performance scale)
• People who have been diagnosed with T-cell lymphoblastic leukemia/lymphoma (a type of blood or lymph system cancer) according to recognised medical criteria, and whose cancer has come back or did not go away fully after initial chemotherapy treatment
• People whose white blood cell count in the blood is below 50,000 per microlitre at the time of joining — methods to reduce white blood cell counts before joining are allowed
• People whose kidneys and liver are functioning at a minimum acceptable level, as measured by specific blood tests at the time of screening (confirm with trial site for exact values; exceptions may apply in certain liver-related conditions)
• People who agree to use contraceptive measures during the 3 months of treatment and for 3 months after treatment ends

Who may not be able to join:

• People who are currently in complete remission from previous treatment, unless relapse or resistance has been confirmed by bone marrow examination or imaging/tissue testing
• People who have previously received the specific combination of venetoclax and decitabine as treatment for T-cell lymphoblastic leukemia/lymphoma (people who received this combination for a different cancer type and where more than 1 year has passed since their last dose may still be considered)
• People who are pregnant or currently breastfeeding
• People who received systemic (whole-body) cancer chemotherapy, or took part in another clinical trial treatment, within the past 2 weeks
• People whose leukemia is actively affecting the central nervous system (brain and spinal cord)
• People who currently require active treatment for a different type of cancer (people whose other cancer has been cured or is slow-progressing and not currently being treated may be considered, following discussion with the trial investigator)
• People with an active HIV infection, or active hepatitis B or hepatitis C infection (people with no detectable virus on PCR testing may be considered with specialist approval)
• People with uncontrolled bleeding
• People with an uncontrolled infection, whether bacterial, fungal, or viral
• People with an uncontrolled mental illness
• People who are unable to understand the consent process or cannot communicate adequately enough to participate safely
• People whom the trial investigator considers unsuitable for participation or difficult to evaluate properly
• People who are unwilling to participate or who are unlikely to follow the treatment and sample collection schedule required by the study

Important: Always verify eligibility with the trial site directly before applying.