Phase 2 Pancreatitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 80 years old at the time of joining
• You have been diagnosed with recurrent acute pancreatitis or chronic pancreatitis, AND also have diabetes (confirmed by imaging, specific study criteria, blood tests, or current diabetes medication)
• You are able to give written consent and commit to follow-up visits over time
• You have had a stable eye exam within the past year, or your most recent eye exam was stable and you are willing to schedule one during the study (an exception applies if you were diagnosed with diabetes within the last 6 months)
• Your HbA1c (a blood sugar control measurement) is between 6.5% and 10.5% at your first study visit
• You are currently taking diabetes medications (such as metformin or insulin), or no diabetes medications at all — and you are willing to temporarily stop certain medications under close medical supervision if required by the study team
• If you are taking a GLP-1 medication (such as Ozempic, Wegovy, or similar), you have been on a stable dose for at least 3 months, your weight has been stable, and you agree not to increase the dose during the study
• You are willing to check your blood sugar and ketone levels using meters provided by the study

Who may not be able to join:

• You have had an allergic or sensitivity reaction to pioglitazone or empagliflozin, or you take medications that could interact with these drugs (confirm with trial site)
• You are already taking pioglitazone or empagliflozin at the time of your first study visit
• You have been diagnosed with Type 1 Diabetes
• You are currently pregnant or breastfeeding, or a pregnancy test at screening comes back positive
• You have a history of a bleeding disorder (such as hemophilia or von Willebrand disease)
• You have liver disease or significantly elevated liver enzyme levels without a known cause
• You are currently receiving treatment for cancer that involves systemic (whole-body) therapy — minor skin cancer treatments done in a dermatologist's office are generally acceptable
• You have osteoporosis that is not being actively treated, based on the doctor's judgment
• You have had an inflammatory illness (such as a respiratory infection or a pancreatitis episode) within the 30 days before joining
• You have a history of moderate-to-severe heart failure (classified as NYHA Class III or higher) (confirm with trial site)
• Your kidneys are not working well enough (kidney filtration rate below 30 mL/min) (confirm with trial site)
• You have taken part in another clinical trial within 30 days before your first study visit
• You are currently dependent on alcohol, tobacco, or other substances, based on the doctor's judgment
• You are currently following a ketogenic (very low-carbohydrate) diet
• You have autoimmune pancreatitis, pancreatitis caused by a blockage, or have had pancreatic surgery (such as a Whipple procedure, full or partial pancreas removal)
• You have any other condition the study doctor believes could put your safety at risk, such as certain types of anemia, fluid retention, or heart failure
• You have had a serious diabetes-related emergency (diabetic ketoacidosis) or signs of poorly controlled diabetes in the past 6 months, or your ketone levels are too high at your first study visit

Important: Always verify eligibility with the trial site directly before applying.