Phase 2 Multiple Sclerosis Trial, Recruiting NCT06735248 Sponsor: ModernaTX, Inc. Condition: Multiple Sclerosis
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Phase 2 Multiple Sclerosis Trial, Recruiting

NCT06735248
Recruiting Phase 2 🇦🇺 Australian site

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who are in overall stable health, as assessed by a doctor through medical history, physical examination, blood tests, and any previous heart monitoring results.
  • People who have tested positive for the Epstein-Barr virus (a common virus, also known as EBV) in a screening blood test.
  • People who have been diagnosed with relapsing multiple sclerosis (including a first single episode, sometimes called clinically isolated syndrome, or an early finding on a scan without symptoms, called radiologically isolated syndrome) within the past 24 months, and who have had no changes in their neurological symptoms for at least 30 days before the first study visit.
  • People who could become pregnant may still be considered, provided they are not currently pregnant or breastfeeding and are using a highly effective form of contraception.

Who may not be able to join:

  • People who have been acutely unwell or had a fever of 38°C (100.4°F) or higher in the 72 hours before or at the time of their screening or first study visit.
  • People with a history of a medical diagnosis or condition that a doctor judges to be unstable or likely to affect their safety, the study results, or their ability to follow study procedures.
  • People who have received any vaccine not related to this study (including any COVID-19 vaccine) within 28 days before or after any study injection, or who have received a flu vaccine within 14 days before or after any study injection — or who plan to do so within those timeframes.
  • People with any medical, psychiatric, or work-related condition, or a history of drug or alcohol misuse, that a doctor believes could increase risks or affect the study results.
  • People who have taken immune-suppressing medications (including corticosteroids at doses of 10mg per day of prednisone or equivalent or higher) in the 30 days before screening.
  • People with any documented history of inflammation of the heart muscle or the lining around the heart (myocarditis, pericarditis, or myopericarditis).
  • People who have donated 450mL or more of blood or blood products within 28 days before screening, or who plan to do so within 28 days after a study injection.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 6 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Phone: 1-866-663-3762

Australian sites

University of the Sunshine Coast Clinical Trials, Birtinya, Queensland

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
ModernaTX, Inc.
Registry
ClinicalTrials.gov
Start date
16 April 2025
Est. completion
8 January 2029

Where this trial is recruiting

🇦🇺 Australia 🇬🇧 United Kingdom 🇺🇸 United States

1 site(s) in Australia. Confirm current status and contact details directly with the trial site.

Primary endpoints

Number of Participants with Solicited Local and Systemic Adverse Reactions (ARs); Number of Participants with Unsolicited Adverse Events (AEs); Number of Participants with Medically Attended Adverse Events (MAAEs); Number of Participants with Adverse Events of Special Interest (AESI), Serious Adverse Events (SAEs) and AEs Leading to Discontinuation of Study Intervention and/or Study Participation

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 6 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov