Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given written consent to participate.
• People aged 18 or older.
• People diagnosed with liver cancer (HCC) or bile duct cancer (ICC) — whether newly diagnosed or with suspected cancer that has come back, remained after treatment, or stopped responding to treatment (Baskets 1 and 2); OR people with certain types of neuroendocrine tumours of the gut, pancreas, or digestive system that are growing or progressing, including specific subtypes based on tumour markers or genetic mutations (Basket 3) — (confirm with trial site for which basket applies).
• People who have at least one tumour that can be measured using a CT or MRI scan with contrast dye, according to standard measurement guidelines.
• People whose general health and ability to carry out daily activities falls within an acceptable range on a standard medical scale (ECOG score of 0, 1, or 2).
• People with liver scarring (cirrhosis) whose liver function is within a certain acceptable range on a standard scoring system (Child-Pugh score of B7 or lower).
• People who are enrolled in or covered by a national health service.

Who may not be able to join:

• People with a known allergic reaction to the study imaging agent (89Zr-TLX250), any of its ingredients, or to contrast dyes used in scans.
• People who have received chemotherapy, extensive radiation, immunotherapy, targeted therapy, or certain blood vessel-related treatments within the 2 weeks before the study imaging agent is given.
• People who have received a radioactive targeted therapy treatment within 3 months before joining the trial.
• People who have had radioembolisation (a type of internal radiation treatment) within 3 months before joining the trial.
• People with cancer that has spread to the brain or spinal cord and is not currently under control.
• People with significant heart disease classified at a serious level on a standard heart disease scale (New York Heart Association class III or IV).
• People whose life expectancy is estimated to be less than 4 months.
• People who have had major surgery within the 4 weeks before enrolling.
• People with serious uncontrolled medical, psychiatric, or surgical conditions — such as active infection including HIV, unstable chest pain, irregular heart rhythm, poorly controlled high blood pressure, poorly controlled diabetes, uncontrolled heart failure, or abnormal lab results — that the trial doctor believes could put the person at risk or affect their ability to participate.
• People with another known cancer diagnosis, unless it was a fully removed non-melanoma skin cancer or cervical cancer in situ, or unless the cancer was definitively treated and there has been no sign of it returning for at least 2 years.
• People who are pregnant or breastfeeding. Women who could become pregnant will have a blood pregnancy test at the start of the study.
• People who are under legal guardianship or trusteeship.
• People who are under judicial protection.

Important: Always verify eligibility with the trial site directly before applying.