Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed an informed consent form and are willing and able to follow the study requirements.
• People who are 18 years of age or older.
• People diagnosed with certain types of aggressive B-cell lymphoma that carry a high risk of the cancer spreading to the brain, including: Diffuse Large B-cell Lymphoma (DLBCL) with a high CNS risk score (4 or above); advanced-stage High Grade B-cell Lymphoma with certain gene changes (MYC, BCL2, and/or BCL6); DLBCL that started in the breast, testicle, skin of the leg, or blood vessels; advanced-stage DLBCL in people living with HIV; or DLBCL involving certain organs (such as the kidney, adrenal gland, bone marrow, spine area, nose/sinuses, uterus, testicle, or skull) combined with a high CNS risk score.
• People whose DLBCL developed from a previously slower-growing (indolent) B-cell lymphoma, as long as the cancer has never previously spread to the brain or spinal fluid.
• People who are planned to receive standard chemotherapy combined with immunotherapy as their treatment.
• People who are able to safely undergo a lumbar puncture (a procedure to collect fluid from around the spine), with no conditions that would make this unsafe.
• People who have not yet received any systemic (whole-body) treatment for an aggressive B-cell lymphoma before joining the study — prior treatment for a slower-growing lymphoma is permitted, and limited short-term steroid use may also be permitted (confirm with trial site).
• People with a general health and activity level rated 0 to 2 on the ECOG scale, meaning they are fully active to capable of basic self-care (confirm with trial site for exact definition).

Who may not be able to join:

• People who have received active systemic treatment for another cancer (other than a slow-growing B-cell lymphoma) within the past 2 years — note that local treatments like surgery or targeted radiation given with the aim of curing another cancer within 2 years may still be permitted (confirm with trial site).
• People who currently have another active cancer, with the exception of certain low-risk or localised cancers such as basal cell skin cancer, localised squamous cell skin cancer, localised prostate cancer, or early-stage cancers in the cervix, breast, or bladder.
• People with an uncontrolled medical condition that, in the doctor's judgement, would make it unsafe to receive intensive chemotherapy — for example, serious active infections, uncontrolled high blood pressure, chest pain, heart rhythm problems, lung disease, or autoimmune conditions.
• People with a known active infection (bacterial, viral, fungal, or other) at the time of joining the study, or who have needed intravenous antibiotics or a hospital stay for an infection within the 2 weeks before starting treatment.
• People with a psychiatric illness or personal circumstances that would significantly affect their ability to safely participate in or follow the study requirements.

Important: Always verify eligibility with the trial site directly before applying.