Phase 2 Alopecia Areata Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old and have moderate to severe hair loss from alopecia areata (affecting more than 30% of the scalp).
• You have been diagnosed with patch-type alopecia areata, alopecia totalis, or alopecia universalis.
• Your hair loss has been present for at least 3 months.
• There is no visible new hair regrowth happening at the start of the study.
• If you are a woman who could become pregnant, you must have a negative pregnancy test before joining.
• If you are a woman who could become pregnant, you must agree to use an effective form of birth control (such as the pill, an injection, an IUD, or surgical sterilization) starting 14 days before the study antibiotics through at least 30 days after the treatment.
• You are not currently taking part in another clinical trial.
• If you are currently taking a JAK inhibitor medication, you are willing to stop taking it for at least 1 month before joining and for the entire length of the study.

Who may not be able to join:

• You currently have an active infection in your digestive system (stomach or intestines).
• You have taken antibiotics within the last 48 hours (though you may be eligible if antibiotics have been stopped for at least 48 hours before treatment).
• You need to continue taking antibiotics on an ongoing basis.
• You have an allergy to the study antibiotics (vancomycin or neomycin).
• You have a known serious condition that affects how your digestive system moves food through, such as gastroparesis or certain complications of scleroderma (confirm with trial site).
• You have a blockage in your small intestine or a condition called ileus (confirm with trial site).
• You have had major surgery on your digestive tract within the last 3 months (note: appendix or gallbladder removal does not count).
• You have had your entire colon surgically removed.
• You are currently receiving intensive chemotherapy, radiation, or biological therapy for cancer.
• You are unable or unwilling to follow the study's requirements.
• Your life expectancy is less than 6 months.
• You have previously received a microbiome transplant treatment (MTT) or any microbiome-based product.
• You have a history of severe, life-threatening food allergies.
• You have received a solid organ transplant within the last 90 days or are being treated for organ rejection.
• You have another condition that could put your safety at risk, make it unlikely you would finish the study, or affect the study results.
• You have a skin condition affecting your scalp, such as psoriasis or seborrheic dermatitis, or any signs of infection or skin cancer on the scalp.
• Your alopecia areata diagnosis is uncertain.
• There is already visible hair regrowth in the areas to be treated at the start of the study.
• You have an active serious medical condition or cancer (except certain minor treated skin cancers) that the study doctor believes would increase your risk, including a history of frequent infections.
• You are unwilling or unable to stop using treatments known to affect hair regrowth in alopecia areata.
• You have used certain hair loss treatments — including steroid injections, steroid tablets, minoxidil, JAK inhibitors, or other related medications — within one month before the start of the study.
• The study doctor considers your diet to be extreme.
• You are currently pregnant or breastfeeding.

Important: Always verify eligibility with the trial site directly before applying.