Motor Neurone Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part, have been fully informed about the study, and agree to sign a consent form and follow all study procedures.
• You are between 18 and 80 years old (any gender), and if you are 18 or older with ALS, you weigh more than 40 kilograms (about 88 pounds).
• You have been diagnosed with ALS (Amyotrophic Lateral Sclerosis) according to specific 2020 diagnostic guidelines called the "Gold Coast Criteria," at a "confirmed" or "probable" level.
• Tests (clinical, nerve, or tissue tests) show signs that the lower part of your nervous system's motor pathways is affected.
• You score 1 or higher on a frailty assessment scale called the Frailty Phenotype scale (confirm with trial site).
• Other diseases have been ruled out as the cause of your symptoms.
• You agree to provide blood, stool, and urine samples during the study for research purposes.

Who may not be able to join:

• You have another neurological condition with symptoms similar to ALS, such as neck or back spine problems or dementia.
• You have an autoimmune disease such as Multiple Sclerosis, Rheumatoid Arthritis, Lupus, Myasthenia Gravis, or similar conditions.
• Your kidneys are not working well enough (based on a specific kidney function test result below a certain level).
• Your liver is significantly damaged, shown by abnormal liver blood tests or a known liver condition such as hepatitis or cirrhosis.
• You have a serious lung condition such as COPD or pulmonary fibrosis.
• You have had a heart attack or a heart procedure in the last 6 months, or you have moderate-to-severe heart failure.
• You have another serious disease affecting your nervous system, heart, lungs, blood, hormone system, or you have a serious mental illness.
• You have a known or suspected history of alcohol or drug abuse.
• Your expected survival is 3 months or less.
• You are pregnant, breastfeeding, or planning to become pregnant, or you are unwilling to use effective contraception from the start of the study until 3 months after stopping the study medication (this applies to both women and men whose partners could become pregnant).
• You are known to be allergic to any ingredients in the trial treatment, or you have a history of serious allergic reactions.
• Researchers believe you may misuse the study drugs in a way that could affect the results.
• You have any other serious physical or mental health condition, or abnormal test results, that researchers feel would make participation unsafe or unsuitable.
• You have or have had a malignant (cancerous) tumour.

Important: Always verify eligibility with the trial site directly before applying.