Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a man or woman aged 18 or older (gender eligibility may depend on the type of cancer)
• You are well enough to carry out basic daily activities, ranging from fully active to capable of limited self-care (confirmed by a standard health scale called ECOG, scores 0–2)
• You have been diagnosed with one of the following cancers, confirmed by a lab test: head and neck cancer, non-small cell lung cancer, small cell lung cancer, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, bladder/urinary tract cancer, sarcoma, or thyroid cancer
• Your cancer has spread to other parts of the body and has continued to grow or worsen during or after previous treatment
• Your cancer can be measured on a scan (such as a CT or MRI)
• You have already received standard, approved treatments for your cancer type that are known to help patients live longer
• You can provide a tumor tissue sample, either from a recent biopsy or from a previously stored biopsy sample
• You have had a CT or MRI scan (and possibly a PET scan) of your chest, abdomen, and pelvis within the last 35 days before starting the study drug
• All previous cancer treatments (such as chemotherapy, surgery, or radiation) were completed at least 1 week before starting the study drug
• Your blood counts, blood clotting, liver function, and kidney function are all at acceptable levels (confirm with trial site)
• You have no active HIV, hepatitis B, or hepatitis C infection, or it is being adequately treated
• If you are a woman who could become pregnant, you have a negative pregnancy test before joining
• If you are a woman who could become pregnant, you are willing to use an approved form of contraception from the start of the study until at least 6 months after your last dose
• If you are a man who could father a child, you are willing to use an approved form of contraception during the study until at least 6 months after your last dose, and to avoid donating sperm for at least 12 months after your last dose
• You are willing and able to attend all scheduled appointments, follow the study plan, and complete all required tests and procedures
• You have read and signed an informed consent form, showing you understand what the study involves, including its experimental nature, risks, and alternatives

Who may not be able to join:

• You have cancer affecting the brain or spinal cord, unless those brain tumors were previously treated with radiation, have been stable for at least 4 weeks, and you no longer need steroid medications for them
• You have a second type of cancer whose symptoms or treatment could affect your safety or interfere with the study results
• You have an active, uncontrolled infection (bacterial, fungal, or viral, including a severe cold or flu) at the time you would start the study drug
• You have serious heart problems or a significant heart-related condition (confirm with trial site)
• You have significant abnormalities on a heart tracing test (ECG) done during screening (confirm with trial site)
• You are pregnant or currently breastfeeding
• You had major surgery within 4 weeks before starting the study drug
• You are taking certain medications that strongly affect how the body processes drugs (specifically strong inhibitors or inducers of CYP3A4 or CYP1A2 — confirm with trial site)
• You have taken a medication known to affect heart rhythm (QT interval) within 7 days before starting the study drug (confirm with trial site)
• You are currently taking part in another clinical trial involving a treatment or imaging study
• You have other health conditions that could interfere with your ability to take part in the study

Important: Always verify eligibility with the trial site directly before applying.