Phase 1 Oesophageal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed (by tissue or cell testing) with either: (Group 1) esophageal cancer of a specific type (squamous cell carcinoma) that cannot be removed by surgery, has spread locally or to other parts of the body, and standard treatments have not worked or are not available; OR (Group 2) a specific type of lung cancer (non-small cell lung cancer — either squamous cell or adenocarcinoma) where standard treatments have not worked or are not available, and your tumor has a certain protein marker (PD-L1) present at a level of 1% or more.
• You are able to provide a tissue sample from within the last year (or results of a PD-L1 protein test already done within the last year) for testing purposes.
• You are willing and able to sign a consent form and follow the schedule of visits and procedures required by the trial.
• You are 18 years old or older.
• Your doctors expect you to live for at least 12 weeks.
• You have at least one tumor that can be measured by CT or MRI scan.
• You are generally able to carry out daily activities, with little or no limitation from your illness (based on a standard medical scoring scale rating you as 0 or 1 out of 4).
• Your blood counts, liver, kidney, and clotting functions all meet certain minimum levels shown by recent blood tests (confirm with trial site for specific values).
• If you are a woman who could become pregnant, or a man whose partner could become pregnant, you are willing to use effective contraception throughout the treatment and for 6 months after it ends.

Who may not be able to join:

• You have previously received any treatment specifically targeting a protein called TIGIT.
• You are currently taking part in another clinical trial that involves a treatment intervention (being in a follow-up or observation-only study may be acceptable — confirm with trial site).
• You have taken any experimental drug within the 4 weeks before starting this trial.
• You have an autoimmune disease, a history of one, or related symptoms.
• You have received any anti-cancer treatment (such as chemotherapy, targeted therapy, immunotherapy, or certain herbal medicines with anti-cancer use) within 4 weeks before starting the trial (some treatments have different waiting periods — confirm with trial site).
• You have taken steroid medications or other drugs that suppress the immune system within the 4 weeks before starting the trial.
• You have received a live vaccine within 4 weeks before starting the trial, or plan to receive one during the study.
• You still have side effects from previous cancer treatments that have not fully resolved (with some exceptions such as hair loss or mild fatigue), or you had a serious immune-related side effect (grade 3 or higher) from previous immunotherapy.
• You have a history of lung inflammation (pneumonia) that required steroid treatment, or you have or have had scarring or inflammation of the lungs (interstitial lung disease).
• You currently have an active infection, such as a bacterial infection, tuberculosis, active hepatitis B or C, or a lung infection.
• You have cancer that has spread to your brain or spinal cord, or to the membranes surrounding the brain.
• You have active hepatitis B or C, HIV, or syphilis based on blood tests (confirm with trial site for specific testing details).
• You have poorly controlled heart problems, such as very high blood pressure, unstable chest pain (angina), a heart attack within the last 6 months, or certain irregular heart rhythms.
• You have severe heart failure (classified as Grade III or IV) or reduced heart pumping function below a certain level.
• You have had another type of cancer within the past 5 years (with some exceptions for certain fully treated, low-risk cancers — confirm with trial site).
• You have a known allergy to the trial drug or similar antibody-based treatments, or you have a history of severe allergic reactions.
• You have a history of alcohol or drug misuse within the year before joining the trial.
• You have a known neurological or psychiatric condition (such as epilepsy or dementia) that might affect your ability to participate.
• You are pregnant or breastfeeding.
• The trial doctor considers you unsuitable for the study for any other reason.

Important: Always verify eligibility with the trial site directly before applying.