Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with squamous cell carcinoma of the esophagus that has spread or cannot be surgically removed, and you have not yet had treatment for this advanced stage of the disease.
• Your cancer can be measured on scans, as assessed by the trial team.
• Any side effects from previous cancer treatments have mostly cleared up (returned to mild or baseline levels), or any hormone-related side effects are being managed with hormone replacement.
• If you are living with HIV, your HIV must be well controlled with medication.
• You are able to carry out daily activities with no or only minimal limitations (based on a standard activity scale used in clinical trials).
• Your liver, kidneys, and other organs are functioning well enough to participate.

Who may not be able to join:

• You have already received systemic (whole-body) treatment for advanced or spreading esophageal cancer.
• Your tumor is growing into nearby organs such as the aorta or airways, which could increase the risk of an abnormal connection forming between body parts (fistula).
• You have fluid build-up around your lungs, heart, or abdomen that is difficult to control and needs frequent draining or ongoing medical management.
• You have significant eye conditions affecting the cornea or eyelids that affect healing.
• You are living with HIV and have a history of Kaposi's sarcoma or a condition called Multicentric Castleman's Disease.
• You have previously received certain types of immunotherapy drugs that target specific proteins on immune cells (such as PD-1, PD-L1, or PD-L2 therapies).
• You have received any systemic cancer treatment, including experimental treatments, within the past 4 weeks.
• You have had radiotherapy within the past 2 weeks, or still have side effects from radiation that require steroid medication.
• You have received a live or live-attenuated vaccine (such as certain flu or shingles vaccines) within the past 30 days.
• You have a heart condition affecting the electrical rhythm of your heart, based on a specific measurement on a heart tracing (ECG) (confirm with trial site).
• You have had a serious heart or cardiovascular event in the past 6 months, such as a heart attack, stroke, severe heart failure, or unstable chest pain.
• You have significant nerve damage or weakness in your hands or feet (peripheral neuropathy) at a moderate or severe level.
• You have an immune system condition, or have been taking immune-suppressing medications or steroids (above a low dose) within the past 7 days.
• You have another cancer that is active or has required treatment within the past 3 years.
• You have active cancer that has spread to the brain or the lining around the brain or spinal cord.
• You have an autoimmune disease (where your immune system attacks your own body) that has needed treatment within the past 2 years.
• You have a history of, or currently have, a lung condition called interstitial lung disease (ILD) or inflammation of the lungs (pneumonitis), or there is suspicion of it that cannot be ruled out (with the exception of a past mild radiation-related lung reaction that did not need steroids).
• You currently have an active infection that requires treatment with medication.
• You have a serious lung condition that significantly affects your breathing.

Important: Always verify eligibility with the trial site directly before applying.