Phase 3 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 years or older.
• People whose general health and ability to carry out daily activities falls within a certain range, as measured by a standard medical scoring system called ECOG (scores 0 to 2, meaning fully active to capable of limited self-care).
• People who have been confirmed through tissue or cell testing to have prostate adenocarcinoma (a specific type of prostate cancer).
• People whose cancer shows a certain protein marker called PSMA, confirmed by a specialised scan (PSMA PET/CT).
• People whose testosterone levels are at a very low "castrate" level, either through medication or surgery.
• People who have previously been treated with two specific types of cancer therapy — a hormone-blocking drug (called an androgen receptor pathway inhibitor) and a chemotherapy containing taxane — and whose cancer has continued to grow during or after a radioactive treatment called Lutetium-177 PSMA therapy.
• People who have at least one area of cancer spread (metastasis) visible on a CT scan, MRI, or bone scan done within 28 days before joining the trial.
• People whose kidney function meets a specific level required by the trial organiser (confirm with trial site).

Who may not be able to join:

• People who have taken part in another experimental drug trial within 28 days before joining.
• People who have previously received any experimental treatment containing a substance called Actinium-225 (225Ac).
• People who have cancer that has spread to the brain or spinal cord and are experiencing neurological symptoms, instability, or are taking steroid medications to manage those symptoms.
• People who have a current or ongoing kidney injury or kidney disease.
• People who already have moderate to severe dry mouth (rated Grade 2 or higher on a standard medical scale).
• People who have a history of uncontrolled high blood pressure, heart attack, chest pain (angina), or heart bypass surgery within the 6 months before signing consent, or who have significant active heart disease.
• People who have had another type of cancer or a blood/lymph system cancer within the past 5 years — with exceptions for certain treated skin conditions (basal cell carcinoma or actinic keratosis with no recurrence in 3 months, or non-invasive colon polyps that have been removed).

Important: Always verify eligibility with the trial site directly before applying.