Phase 1 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a healthy Korean adult between 19 and 50 years old at the time of screening (for the single dose part of the study)
• You are a healthy Korean or Caucasian adult between 19 and 50 years old at the time of screening (for certain parts of the multiple dose study)
• You are a healthy Korean adult between 65 and 85 years old at the time of screening (for one specific group in the multiple dose study)
• Your body weight is between 50.0 kg and 90.0 kg, and your Body Mass Index (BMI — a measure of body weight relative to height) is between 18.5 and 29.9
• You have read and fully understood the trial information and are willing to give written consent to take part and follow the trial's guidelines

Who may not be able to join:

• You have, or have had, a significant medical condition affecting the liver, kidneys, nervous system, immune system, lungs, hormones, blood, heart, urinary system, or mental health
• You have had a stomach or bowel condition or surgery that could affect how the study drug is processed in your body
• You answered "yes" to any question on a suicide-related questionnaire given at screening
• You have had an allergic or significant sensitivity reaction to the study drug (AS-S603) or similar medicines, including aspirin or antibiotics
• You tested positive for hepatitis B, hepatitis C, HIV, or syphilis
• You have a history of drug abuse, or a drug screening test came back positive
• Your blood pressure readings at screening were outside the accepted range (too high or too low) while sitting at rest
• Your heart's electrical activity (measured by an ECG) showed certain abnormal readings or irregular rhythms at screening
• Certain liver enzyme levels or a kidney function measurement in your blood tests were outside the accepted range at screening
• You have taken any prescription medication or herbal medicine in the 2 weeks before the first dose, or any over-the-counter medicines, dietary supplements, or vitamins in the week before the first dose — or you expect to take them
• You have taken certain medicines that affect how the body breaks down drugs (such as barbiturates or clarithromycin) within 1 month before the first dose
• You have taken part in another clinical trial and received a study drug within the past 6 months
• You donated whole blood in the past 2 months, donated blood components in the past month, or received a blood transfusion in the past month
• You are a current smoker
• You regularly drink alcohol, or you are unable to avoid alcohol from 3 days before the first dose until the end of the trial
• You consume a lot of caffeine, or you are unable to avoid caffeine-containing food and drinks from 3 days before the first dose until the end of the trial
• You have recently eaten grapefruit or grapefruit-containing products, or you are unable to avoid them from 3 days before the first dose until the end of the trial
• You have unusual eating habits or are unable to follow the standard meals provided by the trial centre during your stay
• You are a woman who could become pregnant, whose period was not confirmed at screening, who tests positive on a pregnancy test, or who does not agree to use a reliable form of contraception for at least 30 days after the last dose
• You are a man who does not agree to use condoms and ensure your female partner uses a reliable form of contraception throughout the trial and for at least 90 days after the last dose
• You do not agree to avoid donating sperm or eggs throughout the trial and for at least 90 days after the last dose
• You are unable to have a spinal fluid sample taken (cerebrospinal fluid tap), if you are in a group where this is required (confirm with trial site)
• The trial doctors have decided for any other reason that it would not be appropriate for you to take part

Important: Always verify eligibility with the trial site directly before applying.