Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have given their informed consent before any study-related assessments take place
• People aged 18 or older
• People who have a specific type of lymphoma called EBV-positive DLBCL that has come back or stopped responding to treatment, and who have already tried at least 2 different rounds of systemic (whole-body) treatment
• People who have already tried all standard treatment options that could reasonably help their condition
• People whose side effects from previous treatments have mostly resolved to mild or stable levels (nerve-related side effects must be no worse than moderate)
• People whose last cancer treatment finished more than 2 weeks before the start of this study
• People whose cancer can be measured on scans, as defined by specific medical guidelines (confirm with trial site)
• People whose general physical functioning falls within an acceptable range on a standard medical scale (confirm with trial site)
• People whose blood counts, liver function, kidney function, and urine protein levels meet the specific thresholds set by the trial (confirm with trial site)
• People who are sexually active and agree to use effective contraception during the study and for 18 weeks after it ends
• People who are willing and able to attend all scheduled visits, follow the treatment plan, and complete all required tests and procedures

Who may not be able to join:

• People with serious or active heart or lung disease (such as unstable chest pain, heart failure, severe lung disease requiring hospitalisation, or circulation problems in the last 12 months), or significant mental health conditions — though people whose heart conditions have been successfully treated (for example, with a stent) may still be considered
• People whose lymphoma has spread to the brain or the lining around the brain and spinal cord
• People currently using herbal supplements or preparations
• People with a serious uncontrolled medical condition or active infection that could interfere with receiving the study treatment
• People currently taking certain medications that affect how the body processes drugs (specifically those that inhibit or trigger proteins called OATP1B1 or OATP1B3), within a specific washout period of that medication (confirm with trial site for a full list of affected medicines)
• People currently taking proton pump inhibitors (a common type of medication for stomach acid, such as omeprazole or pantoprazole), within a specific washout period (confirm with trial site for examples)
• People who have previously had an organ transplant or a bone marrow transplant from a donor are not automatically excluded, but must have no signs of graft-versus-host disease (GVHD) and must have stopped all immune-suppressing medications
• People with a current dependence on non-prescription drugs or alcohol
• People who are pregnant or breastfeeding
• Women with the potential to become pregnant who do not have a negative pregnancy test (blood or urine) before enrolling
• People with any other serious medical, psychiatric, or laboratory finding that the trial doctors believe would make participation unsafe or affect the reliability of the study results
• People with a specific heart rhythm measurement (QTcF) greater than 470 milliseconds on an ECG
• People who have a condition called Post-Transplant Lymphoproliferative Disease (PTLD)

Important: Always verify eligibility with the trial site directly before applying.