Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with marginal zone lymphoma, confirmed by a tissue biopsy
• You have been diagnosed with follicular lymphoma (CD20-positive, stage 1, 2, or 3a), confirmed by a tissue biopsy
• You have not yet received any systemic (whole-body) treatment for your lymphoma
• Your lymphoma requires treatment because of one or more of the following: a large tumor mass (over 7cm), or three or more affected sites each larger than 3cm
• You have symptoms such as unexplained fever, night sweats, or losing more than 10% of your body weight in the past 6 months
• Your lymphoma is causing other symptoms or putting pressure on vital organs (such as the kidneys, eyes, or digestive system), or causing fluid build-up around organs
• You have follicular lymphoma with a high number of cancer cells circulating in your blood, or your lymphoma is rated high-risk based on a specific scoring system called FLIPI2 (confirm with trial site)
• Your heart, lungs, and other organs are functioning well enough, based on tests done recently before joining the study
• You are willing and able to use reliable contraception (two forms at once) during treatment and for 12 months after your last dose, or to abstain completely from sex during that time
• You are able to take blood-thinning or anti-clotting medication while on the study drug lenalidomide
• You are able to give written consent to participate voluntarily

Who may not be able to join:

• You currently have or test positive for an active hepatitis B infection, or have certain markers in your blood indicating past hepatitis B exposure with detectable virus
• You have chronic hepatitis C or an active hepatitis C infection currently being treated with antiviral medication
• You are HIV positive or have an active HIV infection
• You have previously used the drug lenalidomide
• You have had another type of cancer in the past, unless you have been cancer-free for 5 or more years
• You have significant nerve damage or nerve-related symptoms (such as numbness or pain) that are at a moderate or severe level
• You have another serious illness that is not well controlled
• You currently have an active infection requiring treatment, or have received a live vaccine within the past 14 days
• Your lymphoma has spread to your brain or spinal cord, or has done so in the past
• You are not willing to take blood-thinning or anti-clotting medication as required by the study
• You have had a blood clot in an artery within the past year, or a serious blood clot in a vein (confirm severity level with trial site)
• You are pregnant or breastfeeding, as the study drugs are known to be harmful to unborn babies — women who could become pregnant must have two negative pregnancy tests before starting treatment and agree to regular pregnancy testing throughout the study

Important: Always verify eligibility with the trial site directly before applying.