Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have locally advanced breast cancer that has not spread to other parts of the body, with a tumor and lymph node involvement that falls within certain specific size and spread categories (confirm with trial site)
• Your breast cancer has been confirmed by a central lab to be either "triple-negative" or a specific low-hormone type that will be treated like triple-negative breast cancer
• If you have Hepatitis B, you may still be eligible if you have been on antiviral treatment for at least 4 weeks and the virus is undetectable in your blood
• If you have a history of Hepatitis C, you may still be eligible if the virus is currently undetectable in your blood
• You are generally well enough to carry out light activity and care for yourself (a standard health rating of 0 or 1 on a medical scale), assessed within the last 28 days
• Your heart is pumping blood effectively, with a pumping function of 50% or above, confirmed by a heart scan

Who may not be able to join:

• You have serious or poorly controlled heart disease
• You have, or have had, cancer that has spread to the lining around the brain or spinal cord
• You have a significant eye or cornea condition
• You have HIV along with a history of a specific HIV-related cancer (Kaposi sarcoma) or a rare immune system disorder (multicentric Castleman disease)
• You have an ongoing, uncontrolled infection caused by bacteria, fungus, or a virus
• You have previously been treated with certain immunotherapy drugs that target the immune system's "checkpoint" pathways (such as anti-PD-1 or anti-PD-L1 therapies)
• You have received any prior treatment for your current breast cancer diagnosis, including radiation, drug therapy, or surgery
• You have previously been treated with certain targeted antibody drugs or a specific type of antibody-drug combination therapy (confirm with trial site)
• Your breast cancer has spread to other parts of the body (Stage IV) or has spread to certain higher-level lymph nodes (confirm with trial site)
• You have another cancer that is still active or has required treatment within the last 5 years
• You have cancer that has spread to your brain or the fluid around your brain or spinal cord
• You have ever had a lung condition called interstitial lung disease or pneumonitis, or are currently suspected of having it
• You currently have an active infection that requires treatment with medication
• You have both Hepatitis B and Hepatitis C infections at the same time
• You have serious breathing difficulties caused by a current lung illness

Important: Always verify eligibility with the trial site directly before applying.