Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are 18 years of age or older at the time of signing the consent form
• People with a confirmed advanced solid tumour that has come back or stopped responding to treatment, and for whom no standard treatment is available, or who were unable to receive or tolerate standard treatment
• People with a confirmed type of blood cancer (specifically diffuse large B-cell lymphoma, follicular lymphoma, or mantle cell lymphoma) that has come back or stopped responding to treatment, and for whom no standard treatment is available, or who were unable to receive or tolerate standard treatment
• People whose cancer can be measured or detected on scans (such as CT or MRI) according to specific size and measurement standards
• People whose overall health and ability to carry out daily activities meets a certain minimum level (confirm with trial site)
• People whose side effects from previous cancer treatments have largely resolved, except for hair loss or certain stable hormone-related side effects from prior immunotherapy

Who may not be able to join:

• People with a known allergy or sensitivity to the trial drug (JBZ-001) or any of its ingredients
• People with a certain abnormality in their heart's electrical activity, measured by a specific ECG reading (confirm with trial site)
• People who have had a significant heart condition — such as severe heart failure, a heart attack, stroke, unstable chest pain, or an unstable heart rhythm — within the 3 months before starting the trial
• People who have another active cancer that requires treatment, unless that cancer has been completely cured or has very little chance of returning or growing
• People with solid tumours who have fluid build-up causing symptoms in the abdomen or around the lungs (unless stable for at least 2 weeks after treatment for those conditions)
• People with solid tumours who have active cancer spread to the brain or the lining of the brain, unless the brain metastases were previously treated and have been stable for at least 2 weeks, and steroid use is at or below a low dose (confirm with trial site)
• People with a known active HIV infection who are on antiviral medication (note: HIV testing is not required as part of the screening process)
• People with a known active hepatitis B or hepatitis C infection (note: testing for these is not required as part of the screening process)
• People with any other active infection currently requiring treatment with systemic medication
• People who have had major surgery within 4 weeks, or minor surgery within 2 weeks, before starting the trial (excluding certain spinal stabilisation procedures)
• People who have had bowel surgery or other procedures that may affect how a tablet or capsule is absorbed or swallowed
• People with any other medical condition that the trial doctor believes could interfere with the trial results, increase health risks, or make it difficult to attend all required visits and assessments
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.