Alzheimer's Disease Trial, Recruiting NCT06801639 Sponsor: The University of Texas Health Science Center at San Antonio Condition: Alzheimer's Disease
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Alzheimer's Disease Trial, Recruiting

NCT06801639
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are willing and able to understand and sign a consent form agreeing to take part in the study.
  • You are 60 years old or older.
  • You have been diagnosed with Alzheimer's disease (possible or probable), or have mild memory and thinking problems (mild cognitive impairment) that have been linked to Alzheimer's through brain scans or fluid tests.
  • A doctor has assessed your condition and found it ranges from mild memory/thinking problems to moderate dementia, based on a standard rating scale.
  • You are experiencing emotional or mood-related symptoms — such as depression, anxiety, irritability, elevated mood, or low motivation — and these symptoms reach a certain level of severity on a standard questionnaire.
  • You have a caregiver who is willing to be present during treatment sessions and complete questionnaires as part of the study.
  • You can speak and read in English.
  • Your medications have been at a stable dose for at least one month.
  • You have access to a reliable broadband internet connection at home.

For the caregiver (if applicable):

  • You are an adult who provides unpaid care for the person enrolled in the study.
  • You have enough mental capacity to give verbal consent to take part in the caregiver part of the study.
  • You are able to read, write, hear, and communicate well enough to answer questions about the participant's health and help during treatment sessions.

Who may not be able to join:

  • You have unstable or poorly controlled medical conditions (such as unstable chest pain, uncontrolled diabetes or high blood pressure, or advanced cancer) that a doctor feels would make participation unsafe.
  • You have a history of serious psychiatric conditions such as bipolar disorder, schizophrenia, or manic depression.
  • You have a history of epilepsy.
  • You have any metal objects in your head or skull, or anywhere that could interfere with the brain stimulation used in this study.
  • You have had thoughts of suicide with some intention to act on them in the past 3 months, as assessed by a standard scale.
  • You are unwilling to have an MRI scan at the start of the study and during an early check-in period, unless you have a confirmed medical reason why MRI is unsafe for you (such as having a pacemaker or other implanted metal).
  • You are currently taking part in another clinical trial involving a treatment or therapy.

For the caregiver (if applicable):

  • You do not meet all of the caregiver inclusion criteria listed above.

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 28 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Thiago Macedo e Cordeiro, MD, MSc, The University of Texas Health Science Center at San Antonio

Phone: 210-450-7055

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Sponsor
The University of Texas Health Science Center at San Antonio
Registry
ClinicalTrials.gov
Start date
15 July 2025
Est. completion
1 February 2028

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Neuropsychiatric Inventory Questionnaire (NPI-Q) severity score; Brief Dimensional Apathy Scale (bDAS); Caregiver version of the Irritability Questionnaire (IrQ) How often; Caregiver version of the Irritability Questionnaire (IrQ) How much; Cornell Scale for Depression in Dementia (CSDD); Generalized Anxiety Disorder-7 Scale (GAD-7); Montreal Cognitive Assessment (MoCA)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov