Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People of any age may be considered for this trial.
• People who have been diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia or lymphoma (ALL), or a mixed/unclear type of acute leukemia (based on 2022 world health organisation classifications), and whose bone marrow test within the past 30 days shows less than 5% abnormal cells (blasts).
• People who had a prior blood or bone marrow condition (such as myelofibrosis, myelodysplastic syndrome, chronic myeloid leukemia, or a related condition) before developing acute leukemia may still be considered, as long as they have already received at least 4 cycles of a specific type of medication (called a DNA methyltransferase inhibitor, such as azacitidine or decitabine) or at least one round of intensive chemotherapy.
• People who do not have active leukemia spreading outside the bone marrow or to the brain/spinal fluid — though people whose leukemia in those areas was successfully treated into remission may still be considered.
• People who have a suitable stem cell or bone marrow donor available, either a matched family member, a matched unrelated donor, a half-matched family member, or a partially matched unrelated donor.
• People who are planned to receive a bone marrow transplant using a specific anti-rejection medication called post-transplantation cyclophosphamide (PTCy).
• People whose heart, liver, and lung function meet certain minimum levels as determined by their medical team.
• People who are already enrolled in other transplant-related clinical trials may still be considered, as long as there are no conflicts with this trial's treatment plan.

Who may not be able to join:

• People whose leukemia involves a specific genetic change called the PML/RARA fusion (a type known as acute promyelocytic leukemia).
• People who have a documented prior diagnosis of a bone marrow condition (such as myeloproliferative neoplasm, myelodysplastic syndrome, or a related overlap condition) before their leukemia diagnosis, and who have not met the treatment requirements described above (confirm with trial site).
• People who have previously had a bone marrow or stem cell transplant from a donor.
• People whose general physical condition is too poor, based on standard medical scoring tools used by doctors to assess overall health and ability to perform daily activities (confirm with trial site for specific score thresholds).
• People who have another active cancer with a life expectancy of less than 2 years because of that other cancer.
• People with symptomatic coronary artery disease (active heart problems related to blocked arteries).
• People with an infection that is not currently under control.
• People who are pregnant or breastfeeding.
• People with a body mass index (BMI) above 45 (a measure of body weight relative to height).

Important: Always verify eligibility with the trial site directly before applying.