Motor Neurone Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People diagnosed with Parkinson's disease who show at least 2 of the 4 main symptoms (tremor, muscle stiffness, slowness of movement, or symptoms starting on one side of the body), where one of those symptoms must be tremor or slowness of movement
- People with Parkinson's disease whose symptoms have responded to common Parkinson's medications (such as Levodopa or dopamine agonists), or who have not yet had a proper trial of these medications
- People diagnosed with probable Alzheimer's disease (confirmed using specific brain scans or spinal fluid tests showing signs of the disease)
- People diagnosed with ALS (motor neurone disease), confirmed as "definite" or "probable" through specific established medical guidelines and laboratory tests
- People diagnosed with a type of dementia called Frontotemporal Dementia (FTD), confirmed using brain scans or spinal fluid tests
- People who have both ALS and FTD, diagnosed using recognised medical guidelines
Who may not be able to join:
- People with Parkinson's disease who have a pre-existing psychiatric condition (such as a mental health disorder diagnosed before this study)
- People with Parkinson's disease who also have another brain or nerve condition such as multiple sclerosis, ALS, Alzheimer's, neuromuscular diseases, or epilepsy
- People with Parkinson's disease who have also been diagnosed with dementia
- People with Alzheimer's, FTD, or ALS who have a pre-existing psychiatric condition
- People with Alzheimer's, FTD, or ALS who have previously been diagnosed with another neurodegenerative brain disease
- People with Alzheimer's, FTD, or ALS who are unable to sign a consent form agreeing to take part
- Healthy volunteers (controls) who have any pre-existing psychiatric condition
- Healthy volunteers who have any neurodegenerative condition such as Parkinson's, multiple sclerosis, ALS, Alzheimer's, neuromuscular diseases, or epilepsy
- Healthy volunteers who have been diagnosed with dementia or depression
- Healthy volunteers who regularly take certain medications including anti-anxiety drugs, antidepressants, antipsychotics, sleeping tablets, or cognitive (memory/thinking) stimulant drugs
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: TERESA ESPOSITO, PhD, IRCCS INM Neuromed
Phone: +39 0865915249
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
motor symptoms of PD patients will be evaluated with Hoehn and Yahr (HY) score; motor and non motor symptoms of PD patients will be evaluated with MDS-UPDRS; clinical evaluation of cognitive impairment of PD, AD, ALS/FTD patients; clinical evaluation of ALS/FTD patients; identification of variants/mutations; Identification of protein complexes in CSF; Bioinformatic analysis for the identification of proteins and molecular pathways involved; Validation of protein complexes in plasma; Association analysis with endophenotypes; Analysis of the biological impact of protein complexes identified in C...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.