Phase 1 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing and able to give informed consent (or have a legal representative who can do so on your behalf)
• You are willing to allow researchers to use tissue samples from a previous tumor biopsy (exceptions may be possible if no sample is available)
• You are 18 years of age or older
• You are reasonably active and able to care for yourself, with a doctor-rated performance score meeting certain minimum levels (confirm with trial site)
• Your doctor expects you to live at least 4 weeks or more
• If you have a brain shunt that is not programmable, you are willing to have it replaced with a programmable one before treatment; if it is already programmable, you are able to tolerate it being functionally closed for at least 2 hours
• You have been previously diagnosed with a specific type of brain tumor — either a grade 3 or 4 IDH-mutant astrocytoma or glioblastoma, or a lower-grade astrocytoma that has now shown signs of progressing to a higher grade on scans
• Your brain tumor has come back or gotten worse after standard treatment, and it has been at least 12 weeks since you finished your initial radiation therapy
• Your tumor has been confirmed by the study's lab to have a specific protein called IL13Rα2 at a sufficient level
• You have no known reasons why you cannot undergo the blood collection procedure (leukapheresis), or receive steroids or the drug tocilizumab
• Your recent blood tests (taken within 14 days before the blood collection procedure) show your white blood cells, platelets, and red blood cells are at acceptable levels
• Your recent liver and kidney function tests are within acceptable ranges
• Your blood oxygen level is at least 95% while breathing normal air
• Your blood tests show you do not have active HIV, hepatitis B, or hepatitis C infections
• If you are a woman who could become pregnant, you have a negative pregnancy test taken within 14 days before the blood collection procedure
• If you or your partner could have children, you agree to use effective birth control or avoid sexual activity that could lead to pregnancy throughout the study and for at least 3 months after the last treatment

Who may not be able to join:

• You are currently receiving a drug called bevacizumab, due to a higher risk of wound complications
• You have not yet recovered from side effects caused by a previous treatment
• You have seizures that are not under control, or you are showing signs of worsening brain function
• You have had a serious allergic reaction to a drug that is similar to the one used in this trial
• You have a significant ongoing illness that is not under control
• You have an autoimmune disease that currently requires medication to suppress your immune system
• You have an active infection that requires antibiotics given through a drip/IV (minor infections like a small scalp infection are not necessarily a barrier — confirm with trial site)
• You have a known history of HIV, hepatitis B, or hepatitis C infection
• You have another active cancer, unless that cancer or its treatment is unlikely to affect the safety or results of this trial (confirm with trial site)
• You are currently pregnant or breastfeeding
• You have any other health condition that the study doctor believes would make it unsafe for you to participate
• The study doctor believes you may have difficulty following all the procedures and requirements of the trial

Important: Always verify eligibility with the trial site directly before applying.