Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Men and women between the ages of 65 and 90
• People who feel their memory is not as good as it used to be, based on answers to two specific questions about memory and mental clarity
• People who score 21 or higher on a standard thinking and memory test called the MoCA
• People whose walking speed is slower than average for their age and sex, measured by timing two short walks of about 4 metres
• People who can walk for at least 2 minutes without a walking aid, and who manage everyday tasks mostly independently (confirmed by a specific questionnaire score)
• People who have a family member or close friend who can provide information about them as an "informant"
• People who have someone in their life willing and able to help administer a brain stimulation device at home (called tDCS)
• People who have access to reliable home WiFi

Who may not be able to join:

• People who did not complete education beyond the 8th grade
• People who have received a formal diagnosis of dementia from a doctor
• People currently diagnosed with a major psychiatric condition, such as schizophrenia, bipolar disorder, or major depressive disorder
• People showing moderate to severe signs of depression, based on a specific questionnaire score
• People with a history of a serious head injury that caused a prolonged loss of consciousness
• People with a history of fainting episodes where the cause was never identified and which may have been seizures
• People with a history of seizures or epilepsy, or who have a parent, sibling, or child with epilepsy (with some exceptions that a specialist neurologist would assess)
• People who were hospitalised in the past three months due to a serious illness, or an injury that significantly affected their walking or balance
• People with any unstable or particularly uncontrolled ongoing medical condition that could become dangerous if a seizure occurred (such as certain heart conditions or asthma)
• People with a substance use disorder within the past six months
• People whose hairstyle or head covering (such as thick braids, a hair weave, an afro, or a wig) would prevent the device's electrodes from making proper contact with the scalp
• People with ongoing chronic dizziness or vertigo
• People who had a heart attack within the past six months
• People currently receiving chemotherapy or radiation therapy for cancer
• People who are legally blind
• People who have a history of, or currently experience, visual hallucinations
• People who have a pacemaker
• People who have contraindications to MRI or the tDCS brain stimulation device — including an unprovoked seizure in the past two years, any ferromagnetic metal in the body, certain implanted medical devices (such as a deep brain stimulator, medication pump, or cochlear implant), or active skin conditions like eczema on the scalp (confirm with trial site)
• People with a history of REM sleep behaviour disorder, which can be an early sign of Parkinson's disease
• People whose current medications or medical history raise concerns — the trial's covering physician will review each person's medications, doses, recent changes, and other factors to decide on eligibility (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.