Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For people with normal cognition (healthy volunteers):

• People aged between 45 and 90 years old, any gender
• People whose memory and thinking have been assessed as normal, with a Clinical Dementia Rating (CDR) score of 0
• People confirmed by a researcher to have no neurological diseases, major long-term illnesses, cancer, or active infections
• People with no family history of Alzheimer's disease or other conditions affecting memory, thinking, or movement
• People who are able to understand and sign a written consent form before any assessments take place
• Female participants must provide medical records showing surgical sterilisation (such as hysterectomy, removal of both ovaries, or tubal ligation), or confirmation of being past menopause for more than one year; those who could still become pregnant must use effective contraception throughout the study
• Male participants must use effective contraception throughout the study and must not donate sperm during this time
• People who are willing and able to follow all study procedures

For people with cognitive impairment:

• People aged between 45 and 90 years old, any gender
• People with a CDR score of 0.5 or higher
• People with a Mini-Mental State Examination (MMSE) score of 24 or below
• People whose brain MRI results support an Alzheimer's disease diagnosis, with no signs of other neurological conditions
• People whose Alzheimer's-related medications have been at a stable dose for at least 30 days before joining the study
• People who can provide written consent themselves, or whose legal guardian or carer can provide it on their behalf
• People who may be accompanied by a carer if needed
• Female participants must provide medical records confirming surgical sterilisation (such as hysterectomy, removal of both ovaries, or tubal ligation)

Who may not be able to join:

• People with serious neurological conditions or significant disorders affecting the digestive, heart, liver, kidney, blood, cancer-related, hormonal, breathing, or immune systems
• People with metal implants incompatible with MRI scans, such as pacemakers, metal devices in blood vessels, insulin pumps, cochlear implants, nerve stimulators, or brain aneurysm clips
• People who cannot tolerate the noise of an MRI machine, or who have a history of claustrophobia (fear of enclosed spaces)
• People who have been exposed to more than 50 mSv of ionising radiation in the past year through other research studies
• People with a history of drug or alcohol misuse
• People who are pregnant or currently breastfeeding
• People whose veins are difficult to access, making repeated blood draws not possible
• People who have used an experimental drug or device with unknown safety or effectiveness within the past month
• People who are allergic to any ingredients in the imaging tracer injection used in the study
• People who have any other condition that the study investigator believes could pose a risk or affect the study's results

Important: Always verify eligibility with the trial site directly before applying.