Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with stage II or III triple-negative breast cancer (TNBC), confirmed by a biopsy, at a specific tumor size and spread level (confirm with trial site for exact staging details)
• Your cancer has been tested and shows little or no estrogen receptor, progesterone receptor, or HER2 protein activity, following standard testing guidelines
• Any type (subtype) of breast cancer tissue is acceptable for this trial
• You are generally healthy and able to carry out daily activities with no or minimal limitations (a doctor will assess this)
• You are able to do a supervised exercise test that measures how your heart and lungs respond to physical activity
• Your body mass index (BMI) is 18.5 or higher (a basic measure of body weight relative to height)
• You are pregnant or breastfeeding (confirm with trial site, as this appears listed under inclusion)
• Your blood, kidney, and liver function are at adequate levels
• Your long-term blood sugar level (HbA1c) is below 10%

Who may not be able to join:

• You have received chemotherapy, immunotherapy, or other cancer-fighting drugs within the last 5 years
• You currently use injectable medications to lower blood sugar (such as insulin)
• You have not fully recovered from side effects or complications of a recent surgery before starting the trial
• You have had previous treatment for breast cancer or another cancer within the last 5 years (with exceptions for certain treated skin cancers or cervical pre-cancer)
• You have another cancer that is still active or has needed treatment in the 5 years before your breast cancer diagnosis (certain treated skin and cervical cancers may be excepted — confirm with trial site)
• You have previously been treated with a type of chemotherapy called anthracyclines
• You have previously received certain types of immunotherapy drugs that affect how the immune system responds to cancer (such as anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4, or similar treatments)
• You have any condition that, in the doctor's opinion, could put your safety at risk or make it hard to follow the trial plan
• You have a serious uncontrolled illness, active bleeding problems, or an active infection such as hepatitis B, hepatitis C, or HIV
• You have an autoimmune disease (where your immune system attacks your own body) that currently requires ongoing medical treatment
• You have type 1 diabetes
• You have a history of alcohol use disorder (as defined by standard medical criteria)
• You have a history of an eating disorder (as defined by standard medical criteria)

Important: Always verify eligibility with the trial site directly before applying.