Schizophrenia Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 65 years old.
- You are able to communicate in English.
- You have an estimated pre-illness IQ above 79, measured by a specific reading test (confirm with trial site).
- You are willing and able to sign a written consent form to take part voluntarily.
- Your medication has stayed the same for at least the past two weeks, and you are currently taking an antipsychotic medication (either as a pill or an injection).
- You have been diagnosed with a psychotic disorder that is not primarily caused by mood problems — for example, schizophrenia, schizoaffective disorder, schizophreniform disorder, or delusional disorder.
- You currently experience a strong belief that others intend to harm you (a persecutory delusion), which has lasted for at least two months and is not thought to be caused by drug or alcohol use, and which scores at a certain level on a clinical rating scale (confirm with trial site).
Who may not be able to join:
- You have a serious physical or neurological health condition known to affect thinking or brain function, such as uncontrolled diabetes, uncontrolled thyroid problems, Cushing's disease, Lupus, Multiple Sclerosis or another disease affecting the nerves, HIV, a brain infection, unstable heart disease, active hepatitis, certain other hormone conditions, cancer affecting the brain, uncorrected vision problems, or a movement disorder called tardive dyskinesia.
- You have had a serious head injury in the past where you were unconscious for more than 30 minutes.
- Your main diagnosis is an alcohol or drug use disorder, or a personality disorder.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 615-343-3839
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in prior expectations of volatility (mu3); Change in unexpected uncertainty (kappa); Change in psychotic Symptom Rating Scale (PSYRATS)- Belief Subscale Total; Change in PANSS Positive Symptoms - Total; BOLD activation change during PRL task, pre/post treatment - prefrontal cortex; BOLD activation change pre/post treatment - striatum; BOLD activation change during PRL task, pre/post treatment - locus coeruleus; Task-based functional connectivity changes during PRL task, pre/post treatment - prefrontal cortex to striatum
Can't join this trial?
Data last synced from ClinicalTrials.gov: 5 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.