Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 20 and 85 years old
• People who are in generally good to moderate overall health, as assessed by standard medical scoring tools (ASA score 1–3 or ECOG score 0–2)
• People who have imaging, physical examination, blood test results (CA125), and/or a tumour biopsy suggesting a high-grade ovarian cancer of a specific type (epithelial)
• People who are scheduled for surgery to remove ovarian cancer, either as a first operation or as a later "interval" debulking surgery
• People who have signed a consent form agreeing to take part
• People who are physically and mentally able to follow the study procedures

Who may not be able to join:

• People who are currently taking part in another interventional clinical trial
• People who have a known allergy to any of the study medications, or to any anti-inflammatory drug (NSAID) or beta-blocker medication
• People who regularly take any type of beta-blocker or COX-inhibiting medication (a type of anti-inflammatory), with the exception of aspirin — though aspirin must be stopped at least 7 days before surgery and not resumed until 3 weeks after surgery
• People who currently have active asthma, or who needed hospital treatment or a change in asthma medication within the past year
• People who currently have an active stomach ulcer or peptic disease
• People who have had a stroke or mini-stroke (CVA or TIA) at any point in the past
• People who have had another cancer within the last 5 years, or who currently have another cancer — exceptions may apply for certain fully treated skin or cervical conditions (confirm with trial site)
• People with kidney failure, indicated by a creatinine blood test result above 1.5
• People with significant liver problems, including cirrhosis or a bilirubin blood test level above 2
• People with significant heart failure (classified as NYHA class 3 or higher)
• People with a slow heart rate of 50 beats per minute or fewer, or with certain heart rhythm problems known as second- or third-degree AV block
• People with right-sided heart failure caused by high blood pressure in the lungs (pulmonary hypertension)
• People who regularly take a heart medication called Digoxin
• People who have a condition called Prinzmetal's angina (a type of chest pain caused by coronary artery spasm)
• People who have been diagnosed with significant enlargement of the heart (cardiomegaly)
• People with a heart rhythm condition called sick sinus syndrome
• People with disease affecting the blood vessels in their arms or legs (peripheral vascular disease)
• People who currently have an unremoved tumour of the adrenal gland called a pheochromocytoma
• People who are pregnant
• People who are taking immune-suppressing medications, including steroid tablets at doses above the equivalent of 10 mg of prednisone per day, or any other immune-suppressing therapy taken within 7 days before the first study drug dose
• People who have an immune deficiency disorder

Important: Always verify eligibility with the trial site directly before applying.