Phase 2 Peripheral Arterial Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (any gender)
• You have been diagnosed with one of these specific types of soft tissue sarcoma, confirmed by a tissue sample test: undifferentiated sarcoma (except small round cell type), synovial sarcoma, angiosarcoma, fibrosarcoma, smooth muscle sarcoma, liposarcoma (except well-differentiated type), pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, desmoplastic small round cell tumor, NOS sarcoma, SMARCA4-deficient sarcoma, malignant phyllodes tumor of the breast, or intimal sarcoma
• Your cancer has spread or come back and cannot be treated with surgery or radiation therapy
• You are generally able to carry out daily activities with little to no limitation (confirm with trial site)
• Doctors expect you to live for more than 3 months
• Your recent blood tests (within the last 7 days) show that your blood cell counts, liver function, and kidney function are within acceptable ranges (confirm with trial site for specific values)
• Your cancer can be measured on scans according to standard medical guidelines
• You (or your legal representative) are willing to sign a consent form agreeing to take part in the study

Who may not be able to join:

• You have previously received treatment for advanced soft tissue sarcoma, unless your cancer came back more than 6 months after completing a lower-dose course of a specific chemotherapy drug called doxorubicin
• You have received any experimental or cancer-fighting drugs within the 4 weeks before joining the trial
• You have previously been treated with certain immune checkpoint or T-cell targeting drugs (such as anti-PD-1, anti-PD-L1, anti-CTLA-4, or similar therapies)
• You have had another type of cancer in the past 5 years, unless it was cervical cancer or skin basal cell carcinoma that has been fully cured
• You have brain or nervous system (meningeal) metastases that are currently causing symptoms, unless they were treated successfully more than 6 months ago and have been stable since
• You are currently experiencing significant active bleeding
• You are pregnant or breastfeeding, or are able to become pregnant and have not been using adequate contraception
• You have a problem with alcohol abuse or drug addiction
• You have an active autoimmune disease (such as lupus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, or similar conditions), or a history of one that could come back — or you are at high risk due to a previous organ transplant requiring immune-suppressing medication (note: certain mild conditions like thyroid hormone replacement or skin conditions not needing systemic treatment may still be eligible — confirm with trial site)
• You need to take high-dose steroid medications (such as prednisone above a certain level) or other immune-suppressing drugs within 14 days before or during the trial (short-term or inhaled/topical steroids for non-autoimmune conditions may be acceptable — confirm with trial site)
• You have had serious heart or lung problems, such as a heart attack, heart failure, unstable chest pain, serious irregular heartbeat, or interstitial lung disease within the past 6 months
• You have HIV, another immune deficiency condition, or have had an organ or stem cell transplant
• You have active hepatitis B or active hepatitis C (note: people who are stable carriers of hepatitis B on treatment, or who have been fully cured of hepatitis C, may still be eligible — confirm with trial site)
• You have a serious neurological or psychiatric condition, a severe active infection, a serious blood clotting disorder, or any other condition that the doctors believe would put you at risk or prevent you from completing the study

Important: Always verify eligibility with the trial site directly before applying.