Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 15 to 80 years old, of any gender
• People diagnosed with a type of blood cancer (lymphoma) where cancer cells test positive for a protein called CD30
• People whose cancer cells show CD30 on more than 10% of cells, confirmed by a laboratory tissue test
• People who have at least one tumour or affected area that can be measured using standard imaging methods
• People who are not suitable for a stem cell transplant using their own cells, or whose cancer came back after having that type of transplant
• People who are not suitable for a treatment called BV (brentuximab vedotin), or whose cancer came back after BV treatment, with CD30 confirmed by a tissue test
• People whose doctors estimate they are likely to survive for at least 3 months
• People who are generally well enough to carry out light activities, based on standard medical fitness scales (ECOG 0–2, KPS above 60%)
• People whose liver, kidney, and heart are functioning well enough to meet specific laboratory and test thresholds (confirm exact values with trial site)
• People with enough healthy blood cells and suitable vein access to allow a blood collection procedure called apheresis
• People whose brain and spinal cord scans (MRI) show the lymphoma has not spread to the central nervous system
• People who are able to have children and are willing to use reliable contraception during the trial
• People (or their legal guardian) who are able to understand and sign a consent form agreeing to take part

Who may not be able to join:

• People who have a serious complication of lymphoma called haemophagocytic syndrome
• People who are pregnant, breastfeeding, or planning to become pregnant within six months
• People who test positive for Hepatitis B (unless the virus is confirmed inactive by DNA testing), Hepatitis C, HIV, or syphilis
• People who have had another type of cancer, unless it was a certain type of skin cancer or early-stage cervical cancer that has been fully treated
• People who received a CD30-targeted antibody treatment within 4 weeks before joining the trial
• People who still have unresolved side effects rated above Grade 1 from any previous cancer treatment
• People with active uncontrolled bleeding or a known condition that causes abnormal bleeding
• People who had a stem cell transplant using their own cells within the past 6 weeks
• People with an active bacterial or fungal infection that is not under control
• People with a known allergy to the study drug or any of its ingredients
• People with an active autoimmune disease that currently requires ongoing medical treatment
• People with a mental health condition that would make it difficult to cooperate with treatment or assessments
• People who have taken part in another clinical trial within 1 month before this study
• People who have previously had a stem cell transplant using cells from another person (allogeneic transplant)
• People with any other condition that the treating doctor feels could interfere with the trial or put the participant at risk

Important: Always verify eligibility with the trial site directly before applying.