Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are willing to take part, have signed a consent form, and are able to attend follow-up appointments
• You have been diagnosed with esophageal cancer confirmed by a tissue biopsy, at a specific stage that has not spread to distant parts of the body (confirm with trial site for exact staging details)
• You are between 18 and 75 years old (male or female)
• You are generally able to carry out daily activities with little to no limitation (your doctor can assess this)
• You have at least one tumor that can be measured or assessed on scans
• You have not received any previous treatment for esophageal cancer, such as radiotherapy, chemotherapy, or surgery
• Your lung function is at an acceptable level to safely undergo esophageal cancer surgery (confirm with trial site)
• You have no medical reasons that would prevent you from having surgery
• Your blood counts, kidney, liver, and blood clotting results are within acceptable ranges as measured by recent blood tests (confirm with trial site for specific values)
• If you could become pregnant, you must use an approved form of contraception during the study and for 6 months after treatment ends, have a negative pregnancy test within 72 hours before joining, and must not be breastfeeding

Who may not be able to join:

• Your cancer has spread to other parts of the body (stage IV) or cannot be removed by surgery
• Your cancer is located in the upper (neck) section of the esophagus
• You have a known allergy to any of the study drugs, including the immunotherapy drug (camrelizumab), albumin-bound paclitaxel, carboplatin, or similar platinum-based drugs
• You have moderate or severe chest or back pain, or there is a risk that your esophagus could develop a hole (perforation)
• You have previously received radiotherapy, chemotherapy, or any other cancer treatment for this cancer
• You have taken strong immune-suppressing medications within the past 2 weeks (with some exceptions — confirm with trial site)
• You received a live vaccine within 4 weeks before starting the study
• You had major surgery or a serious injury within 4 weeks before starting the study
• You have an active autoimmune disease or a history of certain autoimmune conditions (some exceptions may apply — confirm with trial site)
• You have a history of immune system problems, HIV, or have had an organ or bone marrow transplant
• You have significant uncontrolled heart problems, such as heart failure, unstable chest pain, a heart attack within the past year, or serious uncontrolled irregular heartbeat
• You had a serious infection requiring hospital treatment within the past 4 weeks, or have signs of an active infection shortly before joining the study
• You have active tuberculosis (TB) or a history of TB that was not properly treated
• You have active hepatitis B or hepatitis C infections at certain levels (confirm with trial site)
• You have been diagnosed with another cancer within the past 5 years, with some exceptions for certain low-risk skin cancers or early cervical conditions
• You are pregnant or breastfeeding
• In the opinion of the study doctor, other serious medical, psychiatric, or personal circumstances that could affect your safety or ability to take part in the study

Important: Always verify eligibility with the trial site directly before applying.