Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 70 years old
• People whose CT head scan shows a new, spontaneous bleed in a specific area of the brain called the anterior basal ganglia (which includes structures called the caudate, putamen, and pallidum, but not the thalamus)
• People whose brain bleed is between 20 and 80 mL in size, as measured by a standardised method
• People for whom treatment can reasonably be started within 24 hours of stroke symptoms beginning (if the exact time is unknown, the last time the person was seen to be well is used as the starting point)
• People whose level of consciousness, as measured by a medical scoring tool called the Glasgow Coma Score, falls between 5 and 14
• People who were largely independent in daily life before the bleed, as measured by a standard functioning scale (score of 0 or 1)

Who may not be able to join:

• People whose brain bleed is caused by a ruptured aneurysm, abnormal blood vessels, Moyamoya disease, a blood clot in a brain vein, a brain tumour, a bleed from a prior stroke, or a repeat bleed within the last year — as confirmed by imaging
• People with only very mild stroke symptoms, as measured by a standard stroke severity scale (score of 5 or below)
• People whose pupils are fixed and dilated on both sides
• People showing a specific type of severe abnormal body posturing that can indicate serious brain injury
• People where the bleed has extended into the fluid-filled spaces of the brain, filling more than half of either of the two main chambers
• People whose bleed is primarily in the thalamus, or a basal ganglia bleed that involves more than 25% of the thalamus
• People with a bleed in the lower or back parts of the brain (including the midbrain, pons, or cerebellum)
• People taking blood thinners that cannot be quickly reversed, unless the treating team is confident that no significant clotting problem remains after treatment
• People with signs of active bleeding in the abdomen, digestive system, urinary tract, or airways
• People with an uncorrected clotting disorder or known bleeding condition
• People with a known platelet count below 75,000 or a clotting measure (INR) above 1.4 after any correction attempts
• People who will need to restart long-term blood thinners within 5 days of the bleed
• People with end-stage kidney disease
• People with a mechanical heart valve
• People with end-stage liver disease
• People with a history of drug or alcohol use that, in the opinion of the trial site investigator, would make it difficult to follow the study requirements
• Females without a documented history of surgical sterilisation or menopause who have a positive pregnancy test
• People with a known life expectancy of less than 6 months before the brain bleed occurred
• People for whom there is no reasonable expectation of recovery, or who have a do-not-resuscitate order or comfort-only care plan in place before enrolment
• People currently taking part in another interventional clinical trial (participation in observational studies does not exclude someone)
• People who are unable or unwilling to provide written consent, and who do not have a legal guardian or representative who can do so
• People who are homeless or who would not be able to attend follow-up appointments

Important: Always verify eligibility with the trial site directly before applying.