Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

(For people being assessed for a first episode of psychosis)

• People who have received a diagnosis (assessed using a standard psychiatric tool called DSM-IV) of one of the following: schizophrenia, schizophreniform psychosis, psychosis not otherwise specified (NOS), brief psychosis, schizoaffective syndrome, or delusional disorder
• People who have been taking antipsychotic medication for less than 4 weeks before joining the trial

(For healthy comparison participants)

• People with no personal history of a major psychiatric disorder, including no history of substance use disorders
• People with no family history of psychotic disorders in close blood relatives (parents, siblings, or children)

Who may not be able to join:

(For people being assessed for a first episode of psychosis)

• People whose psychotic symptoms are primarily related to another dominant psychiatric illness

(For all participants)

• People with a significant physical health condition, or a past or current condition affecting the brain (such as a brain tumour, neuroinflammatory disease, or epilepsy), based on medical history, physical signs, MRI results, or laboratory tests
• People who have been exposed to a significant level of medical radiation (25 mSv or more) in the past year
• Women who are pregnant, breastfeeding, or currently lactating
• People who meet the diagnostic criteria for a substance use disorder (not including nicotine dependence), based on DSM-IV assessment or repeated positive drug tests during the study
• People with any metallic object in the eye, or with certain metallic or electromagnetic implants in the body, or who have experienced claustrophobia (fear of enclosed spaces) during an MRI scan
• People who have had symptoms of a severe bacterial, fungal, or viral infection — including upper respiratory infections with effects on the whole body such as fever — within the 7 days before joining
• People who have taken blood-thinning (antihemostatic) medication within 2 weeks before certain procedures involved in the study (a lumbar puncture and arterial line placement)
• People who have donated blood (one unit or more) in the 90 days before initial screening, plasma in the week before screening, or platelets in the 6 weeks before joining
• People who, for any other reason, the trial investigators or sponsor consider unsuitable — this may include very severe symptoms or signs of aggression or hostility

Important: Always verify eligibility with the trial site directly before applying.