Breast Cancer Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Women aged 18 or older who have been diagnosed with HER2-positive breast cancer
- People whose treating doctor has planned for them to receive Neratinib as part of their cancer treatment, either alone or combined with other therapies
- People with a general health and activity level rated at 2 or below on a standard medical scale, and who are expected to live at least 3 more months (confirm with trial site)
- People whose heart is pumping at least 50% of its normal capacity, as measured by a heart function test
- People whose side effects from any previous cancer treatment have mostly resolved, and whose liver and kidney blood test results are within an acceptable range
- People with adequate blood cell counts and kidney function, as confirmed by blood tests
- People who have no ongoing gut or bowel symptoms such as blood in stools, long-term constipation, or persistent stomach pain
- People with no known structural problems in the digestive tract, as confirmed by a stomach camera test or similar examination
Who may not be able to join:
- People who have significant difficulty swallowing, digesting food, or absorbing medications through the gut
- People with a history of long-term digestive conditions, such as inflammatory bowel disease, tumours in the digestive tract, or conditions that affect nutrient absorption
- People with serious heart conditions that could be affected by the study treatment, including dangerous irregular heartbeats, unstable chest pain, uncontrolled high blood pressure, or certain other heart-related conditions
- People who are known to be allergic to Neratinib, probiotics, a placebo, or a medication called loperamide
- People who have taken part in another clinical trial using an experimental drug within the past 4 weeks, or who have regularly used medications that can cause constipation within the past 6 months
- Women who are pregnant or breastfeeding, or who are unwilling to use reliable contraception during the study
- People whose doctor considers them unsuitable due to any medical, psychological, or personal circumstances that could affect their safety or the reliability of the study results
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: +86 15920589334
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Incidence of Grade ≥3 Diarrhea
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.