Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For Arms A and B (ovarian, peritoneal, or fallopian tube cancer):

• People who have been diagnosed with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer, confirmed by tissue testing
• (Arm A only) People whose cancer has stopped responding to platinum-based chemotherapy (called platinum-resistant disease)
• (Arm B only) People whose cancer was responding to platinum-based chemotherapy but then got worse while being treated with a type of drug called a PARP inhibitor
• People who are expected to live at least 3 months or more
• People who are relatively well and able to carry out daily activities, as measured by a standard health scale (ECOG score of 0 or 1)
• People who are able to swallow and keep down tablets or capsules
• People who have received between 1 and 3 previous cancer drug treatments
• People whose liver, kidneys, and other organs are working well enough (confirm with trial site for specific thresholds)
• People who test negative for pregnancy (for those who could become pregnant)

For Arm C (endometrial cancer):

• People who have been diagnosed with Stage III or IV, returned, or spread endometrial cancer
• People who are expected to live at least 3 months or more
• People who are relatively well and able to carry out daily activities (ECOG score of 0 or 1)
• People who are able to swallow and keep down tablets or capsules
• People who have previously been treated with a platinum-based chemotherapy and an approved immunotherapy drug targeting a protein called PD-L1
• People who have received between 1 and 2 previous cancer drug treatments for endometrial cancer
• People who are able to provide a stored tumour tissue sample or recently prepared tissue slides for testing
• People whose liver, kidneys, and other organs are working well enough (confirm with trial site for specific thresholds)
• People who test negative for pregnancy (for those who could become pregnant)

Who may not be able to join:

For Arms A and B:

• (Arm A only) People whose cancer got worse while being treated with weekly paclitaxel or nab-paclitaxel chemotherapy
• People who have previously taken part in a clinical trial of a drug called relacorilant
• People who still have side effects from previous cancer treatments that have not cleared up to a mild level
• People who have had surgery within the 4 weeks before joining the trial
• People who have had large-area radiation treatment covering more than 25% of the body's bone marrow regions
• People who have a medical condition that requires regular or long-term use of steroid medications (corticosteroids)
• People who are currently taking a drug called mifepristone or similar drugs that affect a hormone receptor called the glucocorticoid receptor
• People who have more than mild nerve damage (numbness, tingling, or pain in hands or feet), from any cause
• People with high blood pressure reading of 150 or higher (top number) or 100 or higher (bottom number)
• People with other uncontrolled health conditions that could affect the trial results or their safety (confirm with trial site)
• People who had a bowel blockage within the 12 weeks before joining the trial
• People who have fluid build-up in the abdomen or around the lungs that requires a procedure to drain it
• People with cancer that has spread to the brain or spinal cord that is untreated or causing symptoms
• People who have had another cancer diagnosis within the 3 years before joining the trial
• People who have received a live vaccine within 30 days before the trial start date

For Arm C:

• People whose cancer got worse while being treated with weekly paclitaxel or nab-paclitaxel chemotherapy
• People who have previously taken part in a clinical trial of a drug called relacorilant
• People who still have side effects from previous cancer treatments that have not cleared up to a mild level
• People who have had surgery within the 4 weeks before joining the trial
• People who have had large-area radiation treatment covering more than 25% of the body's bone marrow regions
• People who have a medical condition that requires regular or long-term use of steroid medications (corticosteroids)
• People who are currently taking a drug called mifepristone or similar drugs that affect a hormone receptor called the glucocorticoid receptor
• People who have more than mild nerve damage (numbness, tingling, or pain in hands or feet), from any cause
• People with other uncontrolled health conditions that could affect the trial results or their safety (confirm with trial site)
• People who had a bowel blockage within the 12 weeks before joining the trial
• People who have fluid build-up in the abdomen or around the lungs that requires a procedure to drain it
• People who have had another cancer diagnosis within the 3 years before joining the trial
• People who have received a live vaccine within 30 days before the trial start date
• People with cancer that has spread to the brain or spinal cord — unless local treatment for it has been completed and steroid medications for that condition have been stopped for at least 4 weeks before starting the trial

Important: Always verify eligibility with the trial site directly before applying.