Chronic Fatigue Syndrome Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Lyme disease by a healthcare provider, meeting certain diagnostic standards (definite, probable, or possible)
• You are willing to share past Lyme disease test results and/or related medical records
• You have received at least 2 separate courses of antibiotics for Lyme disease
• You still have thinking or memory problems that are linked to Lyme disease, even after taking antibiotics
• These cognitive (thinking/memory) problems currently get in the way of daily life or cause you distress
• You show signs of slower-than-usual thinking speed on a screening test given by the study team
• You are willing to stop taking antibiotics for tick-borne illness for at least 4 weeks before the study starts and throughout the 12-week study
• You are willing to avoid starting new medications during the trial unless medically necessary, and to inform the study team of any medication changes
• You live in the US or Canada and are comfortable communicating in English
• You are between 18 and 70 years old
• You have reliable, ongoing access to the internet
• You have a suitable home environment with enough space and a quiet, distraction-free area
• You are able to commit to the full 12-week study period, including 4 weeks of training and an 8-week follow-up visit
• You have an estimated general intellectual ability score of 85 or above (assessed by the study team)

Who may not be able to join:

• You have an unstable, non-Lyme-related chronic health condition that has been a problem in the last 12 months (for example, active cancer, recent heart attack, or poorly controlled high blood pressure)
• You have a severe skin condition or sensitive skin near the forehead area where a device would be used
• You have a history of traumatic brain injury with ongoing symptoms
• You have a history of seizures, or have had a seizure within the last 5 years
• You have had brain surgery
• You have had moderate to severe chronic headaches or migraines within the last month
• You have had a stroke that left lasting effects that could interfere with the assessments
• You have a progressive brain or neurological condition that could affect the study results (confirm with trial site)
• You have a history of intellectual disability or a developmental condition affecting thinking and memory
• You currently have a primary psychiatric disorder that would prevent you from fully participating
• You currently have an alcohol or substance use disorder
• You are currently considered at any level of suicide risk, as assessed by a standard screening tool
• You have had suicidal behavior in the past year
• You have a diagnosis of a psychotic disorder, mania, or bipolar disorder
• You have moderate or severe depression at the time of screening
• You are currently taking opioid-based medications, dissociative drugs (prescribed or otherwise), or other medications the study team believes could affect results
• Your current daily medications have not been at a stable dose for at least 4 weeks before the study begins
• You have a medical device implanted in your head (such as a deep brain stimulator) or neck (such as a vagus nerve stimulator), or metal implants in your head or neck
• You do not have adequate vision or physical ability to use a computer and study equipment regularly, or you are unable to give informed consent
• You are currently pregnant, breastfeeding, or planning to become pregnant during the study
• You are not willing to avoid starting, restarting, or increasing other brain-training programs, cognitive supplements, or similar therapies during the trial

Important: Always verify eligibility with the trial site directly before applying.