Phase 2 Vasculitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are willing and able to sign a consent form, or have someone legally authorized to sign on your behalf.
- You are willing to follow all study procedures and be available for the full duration of the study.
- You are male or female, aged 18 or older.
- You have been diagnosed with systemic Degos disease that is affecting your nervous system, as shown by symptoms, imaging, or lab results.
- You are able to swallow pills and are willing to take the study medication (baricitinib) as directed.
- If you are a woman who could become pregnant, you are not currently pregnant or breastfeeding, and you agree to use highly effective birth control during the study and for 30 days after your last dose.
- You or your legal representative are able to understand and sign a written consent form.
Who may not be able to join:
- You have an active infection that is not responding to treatment.
- Your red blood cell levels (hemoglobin) are too low (confirm with trial site).
- Your platelet count (cells that help blood clot) is too low (confirm with trial site).
- Your white blood cell levels are too low, specifically neutrophils or lymphocytes (confirm with trial site).
- Your liver function test results are more than twice the normal upper limit.
- Your kidneys are not working well enough, based on a specific measurement of kidney function (confirm with trial site).
- Within the past 12 weeks, you have had a blood clot, heart attack, unstable heart disease, stroke, or severe heart failure.
- You have had a shingles (herpes zoster) outbreak with symptoms within the past 12 weeks.
- You have lived with someone who had active tuberculosis (TB) and did not receive proper preventive treatment for TB.
- You have signs of active or latent (inactive) TB infection.
- You have received a live vaccine within the past 12 weeks, or expect to need one during the study.
- You have poor kidney function and would need a certain type of contrast dye for medical imaging (confirm with trial site).
- You are currently breastfeeding.
- You are currently pregnant.
- You have a cancer that is not under control.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Cornelia D Cudrici, M.D., National Heart, Lung, and Blood Institute (NHLBI)
Phone: (301) 402-9841
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Number of participants with stability of existing enhancing lesions in the brain and/or spine observed in MRI; Number of participants with no new enhancing lesions in the brain and/or spine observed in MRI
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.