Phase 2 Oesophageal Cancer Trial, Recruiting NCT06943521 Sponsor: Tanabe Pharma America, Inc. Condition: Oesophageal Cancer
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Phase 2 Oesophageal Cancer Trial, Recruiting

NCT06943521
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Adults aged 18 or older at the time of signing the consent form
  • People whose cancer has at least one measurable area of disease, as seen on scans (using a standard measurement method called RECIST v1.1)
  • People who have already tried at least one prior cancer treatment, and either have no remaining standard treatment options that are expected to help, or are unable to tolerate or have chosen not to continue standard treatments
  • People who are relatively well and able to carry out daily activities (measured by a standard scale called ECOG, with a score of 0 or 1)
  • People with a life expectancy of at least 3 months
  • People with adequate bone marrow function (confirm with trial site for specific values)
  • People with adequate liver function (confirm with trial site for specific values)
  • People with adequate kidney function, as measured by a specific calculation showing the kidneys are filtering at a sufficient rate
  • People who have a confirmed diagnosis of one of the following cancer types: head and neck squamous cell carcinoma, non-small cell lung cancer, esophageal cancer, gastric (stomach) cancer, biliary tract cancer, pancreatic ductal adenocarcinoma, breast cancer, ovarian cancer, cervical cancer, endometrial cancer, prostate cancer, urothelial carcinoma, neuroendocrine tumor or carcinoma, soft tissue sarcoma, or NUT carcinoma

Who may not be able to join:

  • People whose cancer has spread to the brain or the lining around the brain and spinal cord, and where that spread is currently active
  • People who still have unresolved side effects from previous cancer treatments that are rated at a moderate level or higher (Grade 2 or above), except for hair loss
  • People who have received systemic (whole-body) cancer treatment within approximately the last 4 weeks, or radiation therapy within the last 2 weeks, before starting the trial
  • People with a personal history of a heart condition called congenital long QT syndrome, or certain serious abnormal heart rhythms such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes
  • People who have recently taken medications known to affect the heart's electrical activity in a specific way (known as QT prolongation risk) within approximately 2 weeks before starting the trial
  • People whose heart electrical activity screening result (called QTcF interval) shows a reading above 470 milliseconds

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 23 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Head of Medical Science, Tanabe Pharma America, Inc.

Phone: Please E-mail

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Tanabe Pharma America, Inc.
Registry
ClinicalTrials.gov
Start date
18 April 2025
Est. completion
1 August 2028

Where this trial is recruiting

🇯🇵 Japan 🇺🇸 United States

Primary endpoints

Incidence of Adverse Event, Dose limiting toxicities (DLTs); Number of Patients with Adverse events (AEs)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov