Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who had an acute ischemic stroke (a stroke caused by a blocked blood vessel) with symptoms starting between 24 and 72 hours before joining the trial — including strokes noticed upon waking or strokes with an unknown exact start time, where "start time" means the last time the person was known to be well
• People who were largely independent before their stroke (with little to no disability beforehand, as measured by a standard scale)
• People with a moderate to severe stroke score on a standard neurological assessment scale, or a slightly lower score if the stroke has caused a significant disability such as vision loss on one side, speech difficulty, or loss of hand function
• People whose brain scans (using CT or MRI with blood vessel imaging) show a blockage in a specific artery — in the middle, front, or back of the brain, or in the basilar artery — that explains the stroke symptoms
• People whose brain scans show a pattern where only a limited area of brain tissue has been permanently damaged, but a larger surrounding area may still be rescued (confirm with trial site for specific technical thresholds)
• People (or their legally authorised representatives) who are able to provide written consent to participate

Who may not be able to join:

• People whose CT brain scan already shows a large area of established damage
• People with a known allergy to the study drug, tenecteplase
• People whose stroke symptoms are improving rapidly, in the opinion of the treating doctor
• People who are very difficult to rouse or communicate with, have had a recent epileptic seizure, or have another neurological or mental health condition that prevents cooperation with the trial
• People with persistently very high blood pressure (systolic at or above 185 mmHg or diastolic at or above 110 mmHg) even after blood pressure-lowering treatment
• People with very low or very high blood sugar levels at the time of assessment
• People with active internal bleeding, or those considered at high risk of bleeding — for example, those who had major surgery, a significant injury, or bleeding in the gut or urinary tract within the past 21 days, or a needle inserted into a blood vessel in a location where pressure cannot be applied within the past 7 days
• People with known problems with blood clotting due to a medical condition or blood-thinning medication use — including specific situations involving warfarin, newer blood-thinning tablets, heparin, or similar medicines (confirm with trial site for specific details)
• People with known platelet function problems or a very low platelet count (below 100,000/mm³) — note that people taking antiplatelet medicines such as aspirin may still be eligible (confirm with trial site)
• People who have had an ischemic stroke or heart attack in the past 3 months, a previous bleed inside the brain, a severe head injury, brain or spinal surgery in the past 3 months, or a known brain tumour, abnormal blood vessel tangle in the brain, or very large brain aneurysm
• People with a serious terminal illness where survival beyond one year would not be expected
• People for whom the required specialised brain imaging tests cannot be performed
• People whose brain scans show damage already covering more than one-third of the middle cerebral artery territory, or a low score on a specific scale used for basilar artery strokes (confirm with trial site)
• People whose CT or MRI scan shows any current or past bleeding inside the brain
• People with blockages in more than one major brain artery at the same time
• Women who are pregnant, breastfeeding, or unwilling to use effective contraception during the trial period
• People who are unlikely to be able to follow the trial procedures or attend follow-up visits
• People with any other condition that the treating doctor believes could make participation unsafe or interfere with the trial
• People who have participated in another interventional clinical trial within the past 3 months

Important: Always verify eligibility with the trial site directly before applying.