Osteoarthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with knee osteoarthritis (knee joint wear and tear) based on standard medical guidelines
- You have had knee pain for more than 3 months
- Your knee pain has not improved with standard treatments (such as physiotherapy or pain medication) for at least 3 months
- You are between 45 and 75 years old
- Your knee X-rays show a moderate level of joint damage (classified as stage 2 or 3 on a standard medical scale)
Who may not be able to join:
- Your knee joint damage is classified as very mild (stage 1) or very severe (stage 4) on X-ray
- You have serious conditions affecting other parts of your body, such as severe heart, kidney, or liver disease, uncontrolled diabetes, cancer, a weakened immune system, blood disorders, or bone diseases affecting the whole body
- You have a tendency to bleed easily, whether due to a medical condition or a blood-thinning medication (confirm with trial site)
- You currently have an infection anywhere in your body, or specifically in or near the knee
- Your knee osteoarthritis was caused by another condition, such as an inflammatory joint disease, a past injury, or a previous infection
- You have had a significant knee injury within the last year
- Your Body Mass Index (BMI — a measure of body weight relative to height) is over 40
- You have had a full knee or hip replacement surgery within the last year
- You are pregnant
- You have had an injection into a joint within the last 6 months
- Your blood test results show that your haemoglobin (a measure of red blood cells) or platelet levels (cells that help blood clot) are below certain levels (confirm with trial site)
- You are allergic to hyaluronic acid products (a substance sometimes injected into joints)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Blood and synovial fluid TNF-alpha levels; Blood and synovial fluid IL-1beta levels; Blood and synovial fluid TNF-alpha methylation changes; Blood and synovial fluid IL-1beta methylation changes
Can't join this trial?
Data last synced from ClinicalTrials.gov: 2 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.