Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that has come back or stopped responding to treatment, confirmed by a tissue biopsy.
• You have at least one tumor that can be measured on a scan or X-ray (at least 1 cm on a CT or MRI scan, or at least 2 cm on a chest X-ray).
• You have previously received at least one chemotherapy treatment containing platinum (such as carboplatin or cisplatin) for your cancer.
• Your cancer got worse within 6 months of your last platinum-based chemotherapy treatment (this is called platinum-resistant disease).
• You are 18 years of age or older.
• Your general health and ability to carry out daily activities meets a certain minimum level (confirm with trial site).
• Your blood counts, liver function, kidney function, and other lab results are within acceptable ranges (confirm with trial site for specific numbers).
• If you are living with HIV, your immune cell count is healthy, your virus levels are undetectable, and you are on effective HIV treatment with no serious HIV-related infections in the past year.
• If you have had a past hepatitis B or C infection, it has been treated and the virus is no longer detectable in your blood.
• If you have had or currently have another type of cancer, it is either fully treated (at least 2 years ago with no signs of return) or is stable and not currently requiring treatment.
• If you are able to become pregnant, you must agree to use effective contraception during the study and for at least 3 months after the last dose of study treatment.
• You are able to understand and sign a consent form, or have a legal representative who can do so on your behalf.

Who may not be able to join:

• You have previously received weekly paclitaxel chemotherapy for ovarian cancer that had already come back (though having it as part of your very first treatment may be allowed — confirm with trial site).
• You have previously been treated with a type of drug called a BCL-XL inhibitor (such as navitoclax).
• You are currently taking part in another clinical trial or have received an experimental treatment very recently.
• You still have significant side effects from a previous cancer treatment (other than hair loss) that have not fully resolved.
• You are currently taking high-dose steroids (such as prednisone above 10 mg per day) or long-term immune-suppressing medications.
• Your cancer has spread to the brain or spinal fluid and is currently active (previously treated and stable brain metastases may be allowed — confirm with trial site).
• You have had an organ transplant or certain types of immune cell therapy (some stem cell transplant histories may be allowed — confirm with trial site).
• You had a major surgery within the past 8 weeks.
• You have had a serious bowel blockage within the past 8 weeks.
• You have had a build-up of fluid in your abdomen or lungs that needed repeated draining in the past 4 weeks.
• You depend on IV nutrition or regular IV fluids to stay nourished.
• You have an active infection that is moderate or severe, within 2 weeks before starting treatment.
• You have a heart condition involving an abnormal heart rhythm measurement on an ECG, or a history of a specific heart rhythm disorder called Long QT Syndrome (confirm with trial site).
• You have had a significant bleeding episode in the past 4 weeks, or have a condition that makes you prone to serious bleeding.
• You have serious uncontrolled health conditions such as heart failure, unstable chest pain, heart arrhythmia, or are currently on dialysis or an organ transplant waiting list.
• You have had a serious allergic reaction to paclitaxel or similar drugs and have not been able to tolerate it again afterward (those who have successfully received paclitaxel after a prior reaction may still be eligible — confirm with trial site).
• You are currently taking certain medications that strongly affect how the study drugs are broken down by the body (called strong CYP3A4 or CYP2C8 inhibitors or inducers — confirm with trial site for specific medications).
• You are pregnant or breastfeeding, as the study drugs may harm an unborn baby or nursing infant.

**Important: Always verify eligibility with the trial site directly before applying