Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be willing and able to sign a consent form before any study procedures begin.
• You must be generally well enough to carry out daily activities with little or no limitation (this is measured by a standard health scale called ECOG 0 or 1 — confirm with trial site).
• Your doctors estimate you have a life expectancy of at least 3 months.
• You must not be breastfeeding.
• You must have at least one area of disease that can be measured by CT or MRI scan, has not been treated with radiation before, and meets specific size requirements.
• For the dose escalation part of the trial: You have an advanced or spreading solid tumour that shows high levels of a protein called EGFR (confirmed by a lab test), has not responded to or could not be tolerated on standard treatments, and cannot be cured by local treatment. Eligible tumour types include certain cancers of the head and neck, lung, oesophagus, bile ducts, cervix, vulva, bladder/urinary tract, or skin.
• For the dose expansion part of the trial (Group 1): You have a confirmed advanced or spreading head and neck cancer (not nasopharyngeal carcinoma) that shows high EGFR levels, has not responded to or could not be tolerated on standard treatments, and cannot be cured by local treatment.

Who may not be able to join:

• You have uncontrolled cancer that has spread to the brain or spinal cord, or cancer affecting the lining around the brain.
• You have a history of a second type of cancer, unless it was certain skin cancers or early-stage cancers that were fully treated and cured, or another cancer with no known active disease and no treatment in the last 2 years.
• You have a history of moderate to severe heart failure (Class II, III, or IV as defined by a standard heart scale — confirm with trial site).
• You have had a heart attack, heart bypass surgery, unstable chest pain, or a heart stent or similar procedure in the past 24 weeks.
• You have a history of non-infectious lung inflammation (interstitial lung disease or pneumonitis) that needed steroid treatment, or you currently have this condition.
• You have an autoimmune disease that has needed treatment affecting your whole body.
• You are infected with HIV.
• You have active hepatitis B or hepatitis C.
• You are currently taking or have recently taken steroid medicines as a systemic treatment (confirm timing with trial site).
• You have previously been treated with a specific type of immune-activating drug called a 4-1BB/CD137 agent.
• You have received a live vaccine within the past 4 weeks.
• You have recently received immunotherapy, biological therapies, targeted drug treatments, or hormonal therapies (confirm timing with trial site).
• You have recently received radiation therapy (confirm timing with trial site).
• You have recently received chemotherapy (confirm timing with trial site).

Important: Always verify eligibility with the trial site directly before applying.