Phase 2 Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have had moderate-to-severe asthma that has persisted for at least 12 months before the screening appointment.
• You have had at least one asthma flare-up in the past 12 months that required treatment with steroid tablets or injections for 3 or more days.
• Your breathing test results (measured before using a reliever inhaler) fall within a specific range — between 30% and 80% of what is considered normal for someone your age and size (confirm with trial site).
• Your breathing test shows a meaningful improvement after using a reliever inhaler — specifically, a 12% or more increase in airflow plus a specific volume increase (confirm with trial site).
• You have been taking a medium-to-high dose combination inhaler (containing both a steroid and a long-acting reliever) for at least 12 months, with the same dose for at least the past 3 months.
• Your asthma symptom score on a standard questionnaire (called ACQ-5) is 1.5 or higher at the screening visit and before being assigned to a treatment group.
• Your body mass index (BMI) — a measure of weight relative to height — is between 18 and 40.

Who may not be able to join:

• You have any medical or mental health condition, or recent (within the past year) or current thoughts of self-harm or suicide, that could make participation risky or unsuitable, as judged by the study doctor.
• You have been diagnosed with or shown signs of any lung disease other than asthma — such as COPD, emphysema, cystic fibrosis, pulmonary fibrosis, or certain other lung conditions — based on symptoms, breathing tests, or scans within the past 12 months.
• You have or have recently had certain infections, including: a parasitic or worm infection requiring treatment in the past 2 weeks; an infection requiring hospital stay or intravenous antibiotics in the past 60 days; or any serious or unusual infection in the past 6 months.
• You are currently taking, or have previously taken, any medication that is not allowed in this study, or you are unable or unwilling to take a medication that is required.
• You have ever used, or are currently using, any approved or experimental biologic medicine (such as treatments targeting certain immune system proteins) or certain targeted tablets (such as JAK inhibitors) for asthma or related allergic conditions.
• You have taken steroid tablets, injections, or joint injections at any dose within 28 days before the screening visit.
• You have received immunoglobulin therapy (a type of immune protein given by drip or injection) within the past 12 weeks, or have plans to receive it during the study.
• You have had a severe allergic reaction (anaphylaxis) to any antibody-based medicine, or to the specific study drug or its ingredients.
• You have had a procedure called bronchial thermoplasty (a treatment applied to the airways) within the past 24 months.
• You have taken part in another clinical trial or received an experimental drug within 30 days (or longer, depending on the drug) before screening, or plan to join another drug or vaccine study during this trial.

Important: Always verify eligibility with the trial site directly before applying.