Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 60 years of age or older and have been newly diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL)
• You are between 15 and 59 years old, newly diagnosed with B-ALL, and your doctor has determined you are not healthy enough for intensive chemotherapy due to at least one of the following: low physical functioning, serious heart problems, serious lung problems, serious kidney problems, serious liver problems, an infection that is not responding to treatment, documented memory or thinking problems, or other health conditions that make intensive chemotherapy too risky
• You are between 15 and 59 years old, newly diagnosed with B-ALL, are physically well enough for intensive chemotherapy, but have personally chosen not to pursue it (for example, due to concerns about side effects, financial or personal reasons, or quality of life preferences)
• You are 15 years of age or older and your B-ALL has come back or stopped responding to previous chemotherapy, or tests show remaining signs of cancer (called MRD positivity) after prior treatment
• Your heart is pumping at least 40% of its normal capacity, as confirmed by an ultrasound of the heart
• Your kidneys are filtering blood at a sufficient level (creatinine clearance of at least 30 mL/min)
• Your liver function results are within an acceptable range (unless abnormalities are caused by the leukemia itself)
• You are able to breathe without significant difficulty and maintain adequate oxygen levels without needing extra oxygen
• You are able to understand and willingly sign a consent form agreeing to take part
• Your doctor expects you to live for at least 3 more months

Who may not be able to join:

• The leukemia has spread to your brain, spinal cord, or other areas outside the bone marrow
• You currently have another active cancer or one that requires treatment
• You have previously been treated with therapies that target proteins called CD19 or CD22, including certain immunotherapy drugs or CAR-T cell therapies
• You have taken immune-suppressing medications within the 2 weeks before signing the consent form, or you plan to take them long-term during the study
• You have significant heart disease that causes symptoms during minimal activity or at rest (confirm with trial site)
• You have severe chronic liver disease, such as cirrhosis or active hepatitis B or C (though people with certain past hepatitis B or C infections may still be eligible under specific conditions — confirm with trial site)
• You have a history of a serious liver condition involving blocked blood vessels in the liver (VOD/SOS)
• You currently have an uncontrolled bacterial, fungal, viral, or other infection, or you have HIV, syphilis, or an active COVID-19 infection
• You have a history of or currently have a neurological condition such as seizures, stroke, dementia, or certain autoimmune diseases affecting the brain or nervous system
• You have a primary immune system disorder or an active autoimmune disease
• You have had a severe allergic reaction to any of the medications used in this study
• You received a live vaccine within 6 weeks before screening
• You have a psychiatric condition or other issue that may make it difficult to follow the study requirements
• You are pregnant, breastfeeding, or are able to have children but are unwilling to use contraception during the study
• Your doctor has determined for any other reason that this study is not appropriate for you

Important: Always verify eligibility with the trial site directly before applying.